{"doi":"10.1093/genetics/76.4.681","title":"GENETIC CONTROL OF CHROMOSOMAL AND PLASMID RECOMBINATION IN <i>STAPHYLOCOCCUS AUREUS</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Recombination-deficient mutants of Staphylococcus aureus have been isolated and found to have properties similar to those of recombination-deficient Escherichia coli. In addition, one Rec- mutant was found to be defective in the restriction and modification of DNA. There is a marked reduction (∼ 104-fold) in recombination between penicillinase plasmids in the Rec- mutants suggesting that these elements do not encode an efficient recombination system. There is, however, a demonstrable residuum of interplasmid recombination; evidence is lacking on whether this residuum is a plasmid or host function. In the absence of the generalized host recombination system it has been possible to demonstrate that interplasmid recombination occurs during vegetative bacteriophage growth and is presumably mediated by a phage-determined recombination system.</jats:p>","journal":"Genetics","year":1974,"id":688765,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1799392,"name":"R V Goering","orcid":null,"position":1,"is_corresponding":false},{"id":1799393,"name":"R P Novick","orcid":null,"position":2,"is_corresponding":false},{"id":1799391,"name":"L Wyman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"GENETIC CONTROL OF CHROMOSOMAL AND PLASMID RECOMBINATION IN <i>STAPHYLOCOCCUS AUREUS</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Recombination-deficient mutants of Staphylococcus aureus have been isolated and found to have properties similar to those of recombination-deficient Escherichia coli. In addition, one Rec- mutant was found to be defective in the restriction and modification of DNA. There is a marked reduction (∼ 104-fold) in recombination between penicillinase plasmids in the Rec- mutants suggesting that these elements do not encode an efficient recombination system. There is, however, a demonstrable residuum of interplasmid recombination; evidence is lacking on whether this residuum is a plasmid or host function. In the absence of the generalized host recombination system it has been possible to demonstrate that interplasmid recombination occurs during vegetative bacteriophage growth and is presumably mediated by a phage-determined recombination system.</jats:p>","is_dataset_classified":null,"base_score":4.219507705176107,"endowment":4.219507705176107,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4275652","pmcid":"PMC1213096","openalex_id":"https://openalex.org/W2114841880","authors":[],"funders":[],"total_grants":0,"fwci":6.0876,"citation_percentile":0.96362921,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":2}],"oa_status":"closed","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"http://academic.oup.com/genetics/article-pdf/76/4/681/35347298/genetics0681.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/genetics/76.4.681","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4275652","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","Bacteriophages and microbial interactions","RNA and protein synthesis mechanisms","Chromosomes, Bacterial","Conjugation, Genetic","DNA, Bacterial","Drug Resistance, Microbial","Extrachromosomal Inheritance","Genotype","Mutation","Radiation Genetics","Recombination, Genetic","Staphylococcus","Staphylococcus Phages","Transduction, Genetic","Ultraviolet Rays"],"mesh_terms":["Chromosomes, Bacterial","Conjugation, Genetic","DNA, Bacterial","Drug Resistance, Microbial","Extrachromosomal Inheritance","Genotype","Mutation","Radiation Genetics","Recombination, Genetic","Staphylococcus Phages","Staphylococcus","Transduction, Genetic","Ultraviolet Rays"],"keywords":["Recombination","Biology","Genetic recombination","Plasmid","Genetics","FLP-FRT recombination","Bacteriophage","Mutant","Site-specific recombination","Escherichia coli","Cre-Lox recombination","Staphylococcus aureus","Lysogenic cycle","DNA","Molecular biology","Gene","Bacteria","Transgene","Recombinase"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T19:01:32.998540Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}