{"doi":"10.1093/g3journal/jkaf156","title":"An updated compendium of\n                    <i>Caenorhabditis elegans</i>\n                    RNA-binding proteins and their regulation","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Although gene regulation occurs both transcriptionally and post-transcriptionally, systems-level characterizations of RNA-binding proteins are still lacking compared to transcription factors. RNA-binding proteins have gene expression functions that include regulating RNA splicing, localization, translation, and turnover. Mapping the regulatory networks that they are involved in will thus be critical for a comprehensive understanding of gene regulation during development. We updated the wRBP1.0 compendium of putative Caenorhabditis elegans RNA-binding proteins to 928 proteins in WS290 and have cataloged their expression and developmental phenotypes using existing functional genomic resources. Many RNA-binding protein genes are expressed in a cell type- and developmental stage-specific manner in the embryo, emphasizing that RNA-binding proteins can contribute to distinct gene expression patterns. In addition, RNA-binding proteins are highly conserved, and their loss can result in a wide range of developmental defects. This updated compendium will provide a resource for functional studies of RNA-binding protein regulatory networks in C. elegans.</jats:p>","journal":"G3: Genes, Genomes, Genetics","year":2025,"id":588857,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1506609,"name":"John Isaac Murray","orcid":null,"position":1,"is_corresponding":false},{"id":819318,"name":"Felicia Peng","orcid":"0000-0001-8733-0907","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"An updated compendium of\n                    <i>Caenorhabditis elegans</i>\n                    RNA-binding proteins and their regulation","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Although gene regulation occurs both transcriptionally and post-transcriptionally, systems-level characterizations of RNA-binding proteins are still lacking compared to transcription factors. RNA-binding proteins have gene expression functions that include regulating RNA splicing, localization, translation, and turnover. Mapping the regulatory networks that they are involved in will thus be critical for a comprehensive understanding of gene regulation during development. We updated the wRBP1.0 compendium of putative Caenorhabditis elegans RNA-binding proteins to 928 proteins in WS290 and have cataloged their expression and developmental phenotypes using existing functional genomic resources. Many RNA-binding protein genes are expressed in a cell type- and developmental stage-specific manner in the embryo, emphasizing that RNA-binding proteins can contribute to distinct gene expression patterns. In addition, RNA-binding proteins are highly conserved, and their loss can result in a wide range of developmental defects. This updated compendium will provide a resource for functional studies of RNA-binding protein regulatory networks in C. elegans.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40658798","pmcid":"PMC12405884","openalex_id":"https://openalex.org/W4412413559","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM153497","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.13236053,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkaf156/63753790/jkaf156.pdf","host_type":"journal"},{"url":"https://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkaf156/63753790/jkaf156.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/g3journal/article-pdf/15/9/jkaf156/63753790/jkaf156.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/g3journal/jkaf156","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40658798","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12405884/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12405884","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12405884?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA regulation and disease","Animals","Caenorhabditis elegans","RNA-Binding Proteins","Caenorhabditis elegans Proteins","Gene Expression Regulation, Developmental","Gene Regulatory Networks","Gene Expression Regulation"],"mesh_terms":["Animals","Gene Expression Regulation","RNA-Binding Proteins","Caenorhabditis elegans","Gene Expression Regulation, Developmental","Caenorhabditis elegans Proteins","Gene Regulatory Networks"],"keywords":["Compendium","Biology","Caenorhabditis elegans","RNA-binding protein","Computational biology","Caenorhabditis","RNA","Genetics","Evolutionary biology","Gene","Post-transcriptional regulation","systems biology","Gene Expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-22T23:12:20.008697Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}