{"doi":"10.1093/g3journal/jkae206","title":"The N terminus-only ( <i>trans</i> ) function of the adhesion G protein-coupled receptor latrophilin-1 controls multiple processes in reproduction of <i>Caenorhabditis elegans</i>","abstract":"Adhesion G protein-coupled receptors are unique molecules. They are able to transmit classical signals via G protein activation as well as mediate functions solely through their extracellular N termini, completely independently of the seven transmembrane helices domain and the C terminus. This dual mode of action is highly unusual for G protein-coupled receptors and allows for a plethora of possible cellular consequences. However, the physiological implications and molecular details of this N terminus-mediated signaling are poorly understood. Here, we show that several distinct seven transmembrane helices domain-independent/trans functions of the adhesion G protein-coupled receptor latrophilin homolog latrophilin-1 in the nematode Caenorhabditis elegans together regulate reproduction: sperm guidance, ovulation, and germ cell apoptosis. In these contexts, the receptor elicits its functions in a noncell autonomous manner. The functions might be realized through alternative splicing of the receptor specifically generating N terminus-only variants. Thus, our findings shed light on the versatility of seven transmembrane helices domain-independent/N terminus-only/trans functions of adhesion G protein-coupled receptor and discuss possible molecular details.","journal":"G3 Genes Genomes Genetics","year":2024,"id":447438,"datarank":0.33096231132981574,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.03907578897151872,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.03907578897151872,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1265070,"name":"Willem Berend Post","orcid":"0000-0002-2552-6477","position":1,"is_corresponding":false},{"id":764659,"name":"Victoria Elisabeth Groß","orcid":"0000-0001-9131-490X","position":2,"is_corresponding":false},{"id":1265505,"name":"Alexander Bernd Knierim","orcid":null,"position":3,"is_corresponding":false},{"id":1265071,"name":"Christina Katharina Kuhn","orcid":"0000-0001-6705-9048","position":4,"is_corresponding":false},{"id":1265506,"name":"Franziska Fiedler","orcid":null,"position":5,"is_corresponding":false},{"id":1265507,"name":"Darian Benno Tietgen","orcid":null,"position":6,"is_corresponding":false},{"id":1265508,"name":"Johanna Lena Schön","orcid":null,"position":7,"is_corresponding":false},{"id":241125,"name":"Torsten Schöneberg","orcid":"0000-0001-5313-0237","position":8,"is_corresponding":false},{"id":764660,"name":"Simone Prömel","orcid":"0000-0001-7800-7323","position":9,"is_corresponding":false},{"id":1265069,"name":"Daniel Matúš","orcid":"0000-0001-7488-0918","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:59.101070Z","pmid":"39243387","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}