{"doi":"10.1093/g3journal/jkae088","title":"CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in <i>Caenorhabditis elegans</i>","abstract":"CED-1 (cell death abnormal) is a transmembrane receptor involved in the recognition of \"eat-me\" signals displayed on the surface of apoptotic cells and thus central for the subsequent engulfment of the cell corpse in Caenorhabditis elegans. The roles of CED-1 in engulfment are well established, as are its downstream effectors. The latter include the adapter protein CED-6/GULP and the ATP-binding cassette family homolog CED-7. However, how CED-1 is maintained on the plasma membrane in the absence of engulfment is currently unknown. Here, we show that CED-6 and CED-7 have a novel role in maintaining CED-1 correctly on the plasma membrane. We propose that the underlying mechanism is via endocytosis as CED-6 and CED-7 act redundantly with clathrin and its adaptor, the Adaptor protein 2 complex, in ensuring correct CED-1 localization. In conclusion, CED-6 and CED-7 impact other cellular processes than engulfment of apoptotic cells.","journal":"G3 Genes Genomes Genetics","year":2024,"id":480041,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1319680,"name":"Tine Hørning Morthorst","orcid":null,"position":1,"is_corresponding":false},{"id":1319681,"name":"Line E Landgrebe","orcid":null,"position":2,"is_corresponding":false},{"id":1319682,"name":"Anna Dippel Lande","orcid":null,"position":3,"is_corresponding":false},{"id":1319683,"name":"Marie Fuglsang","orcid":null,"position":4,"is_corresponding":false},{"id":1319684,"name":"Stine Bothilde Mortensen","orcid":null,"position":5,"is_corresponding":false},{"id":1319685,"name":"Verónica Feteira-Montero","orcid":null,"position":6,"is_corresponding":false},{"id":1070551,"name":"Helene H. Jensen","orcid":"0000-0002-8426-9802","position":7,"is_corresponding":false},{"id":1150816,"name":"Jonas Bruhn Wesseltoft","orcid":"0009-0006-8368-8972","position":8,"is_corresponding":false},{"id":702044,"name":"Anders Olsen","orcid":"0000-0002-9613-9722","position":9,"is_corresponding":false},{"id":702857,"name":"Rikke Hindsgaul Harders","orcid":null,"position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":null,"created_at":"2026-07-19T02:06:58.305365Z","pmid":"38696649","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}