{"doi":"10.1093/femspd/ftae029","title":"Characterization of beta2-adrenergic receptor knockout mouse model during <i>Chlamydia muridarum</i> genital infection","abstract":"Chlamydia genital infection caused by Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. A mouse model has been developed in our laboratory to better understand the effect of cold-induced stress on chlamydia genital infection and immune response. However, the stress mechanism affecting the host response to Chlamydia muridarum genital infection remains unclear. Here, we demonstrate a role for the beta2-adrenergic receptor (β2-AR), which binds noradrenaline and modulates the immune response against chlamydia genital infection in a mouse model. A successful β2-AR homozygous knockout (KO) mouse model was used to study the infection and analyze the immune response. Our data show that stressed mice lacking the β2-AR are less susceptible to C. muridarum genital infection than controls. A correlation was obtained between lower organ load and higher interferon-gamma production by CD4+ and CD8+ cells of the KO mice. Furthermore, exposure of CD4+ T cells to noradrenaline alters the production of cytokines in mice during C. muridarum genital infection. This study suggests that the blockade of β2-AR signaling could be used to increase resistance to chlamydia genital infection. We value the β2-AR KO as a viable model that can provide reproducible results in investigating medical research, including chlamydia genital infection.","journal":"Pathogens and Disease","year":2024,"id":507294,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366583,"name":"Rajnish Sahu","orcid":"0000-0001-6270-2946","position":1,"is_corresponding":false},{"id":366586,"name":"Vida A. Dennis","orcid":"0000-0003-1409-5605","position":2,"is_corresponding":false},{"id":930820,"name":"Kaitlyn Cook","orcid":"0000-0003-3794-3312","position":3,"is_corresponding":false},{"id":758148,"name":"Alexis Ray","orcid":null,"position":4,"is_corresponding":false},{"id":1358906,"name":"Danielle Baker","orcid":null,"position":5,"is_corresponding":false},{"id":1358907,"name":"Ashlei Kelly","orcid":null,"position":6,"is_corresponding":false},{"id":1358908,"name":"Nathasha Woart","orcid":null,"position":7,"is_corresponding":false},{"id":447353,"name":"Tesfaye Belay","orcid":"0000-0001-9055-3749","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:10:58.484528Z","pmid":"39663211","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}