{"doi":"10.1093/femsle/fnv030","title":"Identification of the correct form of the mis-annotated response regulator Rre1 from the cyanobacterium Synechocystis sp. PCC 6803","abstract":null,"journal":"FEMS Microbiology Letters","year":2015,"id":675232,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1764246,"name":"Rebeca Vidal","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Identification of the correct form of the mis-annotated response regulator Rre1 from the cyanobacterium Synechocystis sp. PCC 6803","abstract":"Two-component systems have been extensively described in the control of gene expression in response to different environmental signals in the cyanobacterium Synechocystis sp. PCC 6803. The Hik34-Rre1 two-component system has been shown to regulate a set of genes under certain stress conditions. Some evidence indicates that another histidine kinase, probably Hik2, is acting upstream of Rre1 in the regulation of some genes in response to hyperosmotic and salt stress. In the present study, a mis-annotation of the Rre1 protein has been identified and the correct version has been functionally characterized in vitro. By using EMSA assays, we have demonstrated that phosphorylation of Rre1 by Hik2 increases the affinity of the response regulator for the adhA promoter region, a gene that has been demonstrated previously to be specifically regulated by the Hik34-Rre1 system. These results suggest that Hik2 might cooperate with Hik34 in the regulation of the adhA gene by transferring the phosphoryl group to Rre1 under salt and hyperosmotic stress conditions.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25714549","pmcid":null,"openalex_id":"https://openalex.org/W2061870858","authors":[],"funders":[],"total_grants":0,"fwci":0.1478,"citation_percentile":0.55702555,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/femsle/article-pdf/362/7/fnv030/23925720/fnv030.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/femsle/fnv030","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25714549","host_type":"repository"}],"fields_of_study":["Photosynthetic Processes and Mechanisms","Biocrusts and Microbial Ecology","Algal biology and biofuel production"],"mesh_terms":["Histidine Kinase","Amino Acid Sequence","Bacterial Proteins","Molecular Sequence Data","Mutation","Phosphorylation","Promoter Regions, Genetic","Protein Kinases","Sodium Chloride","Stress, Physiological","Gene Expression Regulation, Bacterial","Sequence Alignment","Oligonucleotide Array Sequence Analysis","Synechocystis","Molecular Sequence Annotation"],"keywords":["Response regulator","Two-component regulatory system","Histidine kinase","Regulator","Phosphorylation","Synechocystis","Gene","Biology","Kinase","Osmotic shock","Gene cluster","Regulation of gene expression","Cell biology","Cyanobacteria","Biochemistry","Genetics","Bacteria","Bacterial protein","Mutant","Start codon","two-component system","Hik2"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T20:23:20.010249Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}