{"doi":"10.1093/europace/euab021","title":"Diagnostic yield and financial implications of a nationwide electrocardiographic screening programme to detect cardiac disease in the young","abstract":"AIMS: There is limited information on the role of screening with electrocardiography (ECG) for identifying cardiovascular diseases associated with sudden cardiac death (SCD) in a non-select group of adolescents and young adults in the general population. METHODS AND RESULTS: Between 2012 and 2014, 26 900 young individuals (aged 14-35 years) were prospectively evaluated with a health questionnaire and ECG. Individuals with abnormal results underwent secondary investigations, the costs of which were being based on the UK National Health Service tariffs. Six hundred and seventy-five (2.5%) individuals required further investigation for an abnormal health questionnaire, 2175 (8.1%) for an abnormal ECG, and 114 (0.5%) for both. Diseases associated with young SCD were identified in 88 (0.3%) individuals of which 15 (17%) were detected with the health questionnaire, 72 (81%) with ECG and 2 (2%) with both. Forty-nine (56%) of these individuals received medical intervention beyond lifestyle modification advice in the follow-up period of 24 months. The overall cost of the evaluation process was €97 per person screened, €17 834 per cardiovascular disease detected, and €29 588 per cardiovascular disease associated with SCD detected. Inclusion of ECG was associated with a 36% cost reduction per diagnosis of diseases associated with SCD compared with the health questionnaire alone. CONCLUSION: The inclusion of an ECG to a health questionnaire is associated with a five-fold increase in the ability to detect disease associated with SCD in young individuals and is more cost effective for detecting serious disease compared with screening with a health questionnaire alone.","journal":"EP Europace","year":2021,"id":159945,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5163,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":671999,"name":"Aneil Malhotra","orcid":"0000-0002-8670-3764","position":1,"is_corresponding":false},{"id":672000,"name":"Gherardo Finocchiaro","orcid":"0000-0001-7531-6286","position":2,"is_corresponding":false},{"id":672001,"name":"Sameer Parpia","orcid":"0000-0002-9407-5622","position":3,"is_corresponding":false},{"id":672002,"name":"Raghav Bhatia","orcid":"0000-0002-3604-7957","position":4,"is_corresponding":false},{"id":672003,"name":"Andrew D’Silva","orcid":"0000-0002-8700-1545","position":5,"is_corresponding":false},{"id":672004,"name":"Sabiha Gati","orcid":"0000-0002-0199-5092","position":6,"is_corresponding":false},{"id":672005,"name":"Greg Mellor","orcid":"0000-0002-8246-9974","position":7,"is_corresponding":false},{"id":673008,"name":"Rajay Narain","orcid":null,"position":8,"is_corresponding":false},{"id":672006,"name":"Navin Chandra","orcid":"0000-0002-1213-7739","position":9,"is_corresponding":false},{"id":344962,"name":"Elijah R. Behr","orcid":"0000-0002-8731-2853","position":10,"is_corresponding":false},{"id":672007,"name":"Maite Tome","orcid":"0000-0002-8962-3524","position":11,"is_corresponding":false},{"id":672008,"name":"Michael Papadakis","orcid":"0000-0003-0616-2353","position":12,"is_corresponding":false},{"id":58226,"name":"Sanjay Sharma","orcid":"0000-0002-3630-6138","position":13,"is_corresponding":false},{"id":671998,"name":"Harshil Dhutia","orcid":"0000-0002-6749-3271","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T23:44:43.908634Z","pmid":"33570096","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}