{"doi":"10.1093/eurjpc/zwaf012","title":"Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study","abstract":"AIMS: To assess the cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures in samples of the Framingham Heart Study. METHODS AND RESULTS: In 6597 participants [3606 (55%) women, 51.5% never smoked, 34.8% formerly quit, 4.3% recently quit, and 9.3% currently smoking], we assessed relations of smoking behaviour with central arterial measures using multivariable linear regression models. In cross-sectional models, central arterial measures were different across smoking behaviour groups. Particularly, augmentation index (AI) was higher among participants who formerly quit smoking (least squares mean ± standard error = 14.1 ± 0.4%; P < 0.001) and were currently smoking (18.1 ± 0.5%; P < 0.001) compared with participants who never smoked (12.6 ± 0.3%). Among participants currently smoking, higher cigarettes per day [B = 1.41; 95% confidence interval (CI), 0.47-2.34] were associated with higher AI. Among participants who had quit smoking, higher pack-years were associated with higher AI (B = 0.85; 95% CI, 0.60-1.14) and central pulse pressure (B = 0.84; 95% CI, 0.46-1.21). Using restricted cubic splines, we observed a negative linear association for AI, but non-linear associations for characteristic impedance and central pulse pressure, with higher time since quit (all P < 0.001). Additionally, we observed non-linear patterns of central arterial measures with smoking cessation by smoking burden (<20 vs. ≥20 pack-years). In longitudinal models, we observed higher increases in AI among participants who persistently quit (4.62 ± 0.41%; P < 0.001) and persistently smoked (5.48 ± 0.70%; P = 0.002) compared with participants who never smoked (3.45 ± 0.37%). CONCLUSION: Central arterial measures are sensitive to differences and changes in smoking behaviour. Longer cessation may revert central arterial measures to levels observed with lower smoking exposure.","journal":"European Journal of Preventive Cardiology","year":2025,"id":538713,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7663,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":711176,"name":"Sana Majid","orcid":"0000-0002-9968-0178","position":1,"is_corresponding":false},{"id":331285,"name":"Na Wang","orcid":"0000-0002-4936-6244","position":2,"is_corresponding":false},{"id":500879,"name":"Jessica L. Fetterman","orcid":"0000-0002-9286-7538","position":3,"is_corresponding":false},{"id":304493,"name":"Joseph Palmisano","orcid":"0000-0001-6000-3025","position":4,"is_corresponding":false},{"id":1034,"name":"Emelia J. Benjamin","orcid":"0000-0003-4076-2336","position":5,"is_corresponding":false},{"id":24661,"name":"Ramachandran S. Vasan","orcid":"0000-0001-7357-5970","position":6,"is_corresponding":false},{"id":337721,"name":"Gary F. Mitchell","orcid":"0000-0001-5643-3145","position":7,"is_corresponding":false},{"id":455411,"name":"Naomi Hamburg","orcid":"0000-0001-5504-5589","position":8,"is_corresponding":false},{"id":739701,"name":"Leroy L. Cooper","orcid":"0000-0001-9764-0837","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:52:25.799399Z","pmid":"39907713","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}