{"doi":"10.1093/eurjpc/zwae355","title":"The effects of colchicine on lipoprotein(a)- and oxidized phospholipid-associated cardiovascular disease risk","abstract":"AIMS: Inflammatory lipoprotein(a) [Lp(a)] and oxidized phospholipids (OxPLs) on lipoproteins convey residual cardiovascular disease risk. The low-dose colchicine 2 (LoDoCo2) trial showed that colchicine reduced the risk of cardiovascular events occurring on standard therapies in patients with chronic coronary syndrome (CCS). We explored the effects of colchicine on Lp(a)- and oxidized lipoprotein-associated risk in a LoDoCo2 biomarker subpopulation. METHODS AND RESULTS: Lipoprotein(a) and OxPLs on apolipoprotein(a) [OxPL-apo(a)] and apolipoprotein B-100 (OxPL-apoB) levels were determined in the biomarker population of the LoDoCo2 trial (n = 1777). The Cox regression analysis was used to compare the risk of the primary endpoint, consisting of myocardial infarction, ischaemic stroke, or ischaemia-driven revascularization by biomarker levels. Interactions between treatment, Lp(a), and OxPL levels were evaluated. Lipoprotein(a), OxPL-apo(a), and OxPL-apoB levels were similar between the colchicine and placebo groups. Consistent risk reduction by colchicine was observed in those with Lp(a) < 125 nmol/L and ≥125 nmol/L and the highest OxPL-apo(a) tertile compared with the lowest (Pinteraction = 0.92 and 0.66). The absolute risk reduction for those with Lp(a) ≥ 125 nmol/L appeared higher compared with those with Lp(a) < 125 nmol/L (4.4% vs. 2.4%). A treatment interaction for colchicine was found in those with the highest OxPL-apoB tertile vs. the lowest (Pinteraction = 0.04). CONCLUSION: In patients with CCS, colchicine reduces cardiovascular disease risk in those with and without elevated Lp(a) but absolute benefits appeared higher in those with Lp(a) ≥ 125 nmol/L. Patients with higher levels of OxPL-apoB experienced greater benefit of colchicine, suggesting that colchicine may be more effective in subjects with heightened oxidation-driven inflammation.","journal":"European Journal of Preventive Cardiology","year":2024,"id":424833,"datarank":0.6188215864972664,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.15516521849351883,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.15516521849351883,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":15,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1221882,"name":"Amber van Broekhoven","orcid":"0000-0002-4204-7750","position":1,"is_corresponding":false},{"id":1221883,"name":"Willem A. Bax","orcid":"0000-0002-2177-1475","position":2,"is_corresponding":false},{"id":56149,"name":"John W. Eikelboom","orcid":"0000-0003-4126-1285","position":3,"is_corresponding":false},{"id":1221884,"name":"Arend Mosterd","orcid":"0000-0002-6906-2643","position":4,"is_corresponding":false},{"id":1221885,"name":"Aernoud T.L. Fiolet","orcid":"0000-0001-5328-2564","position":5,"is_corresponding":false},{"id":1201394,"name":"Jan G.P. Tijssen","orcid":"0000-0003-1707-2628","position":6,"is_corresponding":false},{"id":1189157,"name":"Peter L. Thompson","orcid":"0000-0002-1873-9925","position":7,"is_corresponding":false},{"id":646521,"name":"Dominique P.V. de Kleijn","orcid":"0000-0003-2714-2140","position":8,"is_corresponding":false},{"id":323538,"name":"Sotirios Tsimikas","orcid":"0000-0001-9834-9494","position":9,"is_corresponding":false},{"id":631962,"name":"Jan H. Cornel","orcid":"0000-0002-1006-2112","position":10,"is_corresponding":false},{"id":633992,"name":"Calvin Yeang","orcid":"0000-0002-5927-9291","position":11,"is_corresponding":false},{"id":1221886,"name":"Saloua El Messaoudi","orcid":"0009-0006-0804-2071","position":12,"is_corresponding":false},{"id":1221881,"name":"Niekbachsh Mohammadnia","orcid":"0000-0002-5968-3817","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:21.523756Z","pmid":"39478683","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}