{"doi":"10.1093/eurjpc/zwae288","title":"Plasma levels of polyols erythritol, mannitol, and sorbitol and incident coronary heart disease among women","abstract":"AIMS: Erythritol, a sugar alcohol (polyol), has recently been linked to the risk of major adverse cardiovascular events. We investigated whether plasma erythritol and other polyols (mannitol/sorbitol) were associated with the risk of incident coronary heart disease (CHD). METHODS AND RESULTS: This prospective nested case-control study included 762 incident cases of CHD and 762 controls from the Nurses' Health Study. Plasma concentrations of polyols were measured at baseline (1989-90 or 2000-02). Associations of erythritol with cardiometabolic risk factors were also analysed in the Women's Lifestyle Validation Study (n = 728; blood collected in 2010-12). Higher erythritol levels were related to more adverse cardiometabolic risk factor status. A relative risk (RR) for CHD per 1-SD increment was 1.15 [95% confidence interval (CI): 1.04, 1.28] for erythritol and 1.16 (95% CI: 1.05, 1.28) for mannitol/sorbitol, after adjusting for diet quality, lifestyles, and adiposity. Compared with women in the lowest quartile, those in the highest quartile (Q4) of erythritol had an RR of 1.55 (95% CI: 1.13, 2.14) for CHD. The RR in the Q4 of erythritol was 1.61 (95% CI: 1.15, 2.24; P = 0.006) when hypertension and dyslipidaemia were further added to the model; the RR was 1.21 (95% CI: 0.86, 1.70) after adjustment for diabetes. For mannitol/sorbitol, the RR in Q4 was 1.42 (95% CI: 1.05, 1.91; P = 0.022) for CHD in the multivariable-adjusted model including diabetes. CONCLUSION: Higher levels of plasma erythritol and mannitol/sorbitol were related to elevated risks of CHD even after adjustment for diet, lifestyles, adiposity, and other risk factors. The unfavourable association of mannitol/sorbitol, but not of erythritol, with CHD risk remained significant independent of diabetes/hyperglycaemia.","journal":"European Journal of Preventive Cardiology","year":2024,"id":438987,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9221,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246331,"name":"Qi Sun","orcid":"0000-0002-8480-1563","position":1,"is_corresponding":false},{"id":913350,"name":"Xuan Wang","orcid":"0000-0002-6588-2951","position":2,"is_corresponding":false},{"id":442157,"name":"Saumya Tiwari","orcid":"0000-0001-5148-6539","position":3,"is_corresponding":false},{"id":233458,"name":"Jeramie D. Watrous","orcid":"0000-0001-9124-6783","position":4,"is_corresponding":false},{"id":17007,"name":"Kathryn Rexrode","orcid":"0000-0003-3387-8429","position":5,"is_corresponding":false},{"id":585503,"name":"Mona Alotaibi","orcid":"0000-0001-8492-9930","position":6,"is_corresponding":false},{"id":233460,"name":"Mohit Jain","orcid":"0000-0001-8628-2069","position":7,"is_corresponding":false},{"id":351263,"name":"Samia Mora","orcid":"0000-0001-6283-0980","position":8,"is_corresponding":false},{"id":104570,"name":"Walter C. Willett","orcid":"0000-0003-1458-7597","position":9,"is_corresponding":false},{"id":21926,"name":"Lu Qi","orcid":"0000-0002-8041-7791","position":10,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":11,"is_corresponding":false},{"id":256514,"name":"Yoriko Heianza","orcid":"0000-0002-0957-9309","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:00:47.992543Z","pmid":"39230875","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}