{"doi":"10.1093/eurjpc/zwad271","title":"Oxidative stress–related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: a Swedish population-based retrospective cohort study","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Aims</jats:title>\n                  <jats:p>The aim of this study is to investigate how genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and any potential interactions between these factors affect the incidence of intact abdominal aortic aneurysm (AAA) and its rupture (rAAA), accounting for sex differences where possible.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results</jats:title>\n                  <jats:p>The present retrospective cohort study (n = 25 252) uses baseline single-nucleotide polymorphisms (SNPs) and total antioxidant vitamin intake data from the large population-based, Malmö Diet and Cancer Study. Cumulative incidence of intact AAA was 1.6% and of rAAA 0.3% after a median follow-up of 24.3 years. A variant in NOX3 (rs3749930) was associated with higher rAAA risk in males [adjusted hazard ratio (aHR): 2.49; 95% confidence interval (CI): 1.36–4.35] and the overall population (aHR: 1.88; 95% CI: 1.05–3.37). Higher intakes of antioxidant vitamins, riboflavin, and folate were associated with 20% and 19% reduced intact AAA incidence, respectively. Interestingly, the inverse associations between riboflavin and vitamin D intake with intact AAA incidence were stronger in the individuals carrying the NOX3 variant as compared with the wild-type recessive genotype, i.e. by 60% and 66%, respectively (P for interaction &amp;lt; 0.05). Higher riboflavin intake was associated with a 33% male-specific intact AAA risk reduction, while higher intake of vitamin B12 intake was associated with 55% female-specific intact AAA risk increase; both these associations were significantly modified by sex (P for interaction &amp;lt; 0.05).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Our findings highlight the role of oxidative stress genetic variations and antioxidant vitamin intake in AAA. Although a low AAA/rAAA sample size limited some analyses, especially in females, our findings highlight the need for future randomized controlled trials and mechanistic studies, to explore the potential benefits of antioxidant vitamins while accounting for genetic and sex differences.</jats:p>\n               </jats:sec>","journal":"European Journal of Preventive Cardiology","year":2024,"id":638131,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":65025,"name":"Kristina Sundquist","orcid":"0000-0001-8031-279X","position":1,"is_corresponding":false},{"id":65027,"name":"Jan Sundquist","orcid":"0000-0001-7228-5015","position":2,"is_corresponding":false},{"id":1657254,"name":"Naiqi Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1280547,"name":"Xiao Wang","orcid":"0000-0003-4206-9199","position":4,"is_corresponding":false},{"id":1231304,"name":"Stefan Acosta","orcid":"0000-0002-3225-0798","position":5,"is_corresponding":false},{"id":84918,"name":"Anders Gottsäter","orcid":"0000-0003-0865-0000","position":6,"is_corresponding":false},{"id":1657255,"name":"Ashfaque A Memon","orcid":null,"position":7,"is_corresponding":false},{"id":1657252,"name":"Sakshi Vats","orcid":"0000-0003-3419-6446","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Oxidative stress–related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: a Swedish population-based retrospective cohort study","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Aims</jats:title>\n                  <jats:p>The aim of this study is to investigate how genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and any potential interactions between these factors affect the incidence of intact abdominal aortic aneurysm (AAA) and its rupture (rAAA), accounting for sex differences where possible.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results</jats:title>\n                  <jats:p>The present retrospective cohort study (n = 25 252) uses baseline single-nucleotide polymorphisms (SNPs) and total antioxidant vitamin intake data from the large population-based, Malmö Diet and Cancer Study. Cumulative incidence of intact AAA was 1.6% and of rAAA 0.3% after a median follow-up of 24.3 years. A variant in NOX3 (rs3749930) was associated with higher rAAA risk in males [adjusted hazard ratio (aHR): 2.49; 95% confidence interval (CI): 1.36–4.35] and the overall population (aHR: 1.88; 95% CI: 1.05–3.37). Higher intakes of antioxidant vitamins, riboflavin, and folate were associated with 20% and 19% reduced intact AAA incidence, respectively. Interestingly, the inverse associations between riboflavin and vitamin D intake with intact AAA incidence were stronger in the individuals carrying the NOX3 variant as compared with the wild-type recessive genotype, i.e. by 60% and 66%, respectively (P for interaction &amp;lt; 0.05). Higher riboflavin intake was associated with a 33% male-specific intact AAA risk reduction, while higher intake of vitamin B12 intake was associated with 55% female-specific intact AAA risk increase; both these associations were significantly modified by sex (P for interaction &amp;lt; 0.05).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Our findings highlight the role of oxidative stress genetic variations and antioxidant vitamin intake in AAA. Although a low AAA/rAAA sample size limited some analyses, especially in females, our findings highlight the need for future randomized controlled trials and mechanistic studies, to explore the potential benefits of antioxidant vitamins while accounting for genetic and sex differences.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37665957","pmcid":null,"openalex_id":"https://openalex.org/W4386414847","authors":[],"funders":[{"funder_name":"Swedish Heart-Lung Foundation","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Swedish Heart-Lung Foundation","grant_id":"","title":null},{"funder_name":"Research Funds at Skåne University Hospital","grant_id":"","title":null},{"funder_name":"Hulda Ahlmroth Foundation","grant_id":"","title":null},{"funder_name":"Region Skåne","grant_id":"","title":null},{"funder_name":"Swedish Government","grant_id":"","title":null},{"funder_name":"Swedish Heart-Lung Foundation","grant_id":"","title":null},{"funder_name":"Research Funds at Skåne University Hospital","grant_id":"","title":null},{"funder_name":"Region Skåne","grant_id":"","title":null},{"funder_name":"Hulda Ahlmroth Foundation","grant_id":"","title":null},{"funder_name":"Swedish Government","grant_id":"","title":null}],"total_grants":11,"fwci":2.0061,"citation_percentile":0.87848854,"influential_citations":1,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwad271/51346777/zwad271.pdf","host_type":"journal"},{"url":"https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwad271/51346777/zwad271.pdf","host_type":"HYBRID"},{"url":"https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwad271/51346777/zwad271.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/eurjpc/article-pdf/31/1/61/54908379/zwad271.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/eurjpc/zwad271","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37665957","host_type":"repository"},{"url":"https://lup.lub.lu.se/record/0b2a64e5-0935-485c-9fc8-1275b9903e75","host_type":"repository"}],"fields_of_study":["Aortic aneurysm repair treatments","Folate and B Vitamins Research","Connective tissue disorders research","Medicine","Environmental Science","Biology","0301 basic medicine","03 medical and health sciences","Humans","Male","Female","Retrospective Studies","Antioxidants","Sweden","Risk Factors","Aortic Aneurysm, Abdominal","Aortic Rupture","Vitamin A","Oxidative Stress","Vitamins","Riboflavin","Genetic Variation"],"mesh_terms":["Antioxidants","Aortic Rupture","Female","Humans","Male","Retrospective Studies","Riboflavin","Risk Factors","Sweden","Genetic Variation","Vitamin A","Vitamins","Aortic Aneurysm, Abdominal","Oxidative Stress"],"keywords":["Medicine","Oxidative stress","Retrospective cohort study","Abdominal aortic aneurysm","Vitamin C","Antioxidant","Internal medicine","Cohort study","Cohort","Population","Surgery","Aneurysm","Environmental health","Biochemistry","Genetics","Vitamins","Sex differences","Male","Sweden","Aortic Rupture","Riboflavin","Genetic Variation","Antioxidants","Risk Factors","Humans","Female","Vitamin A","Retrospective Studies","Aortic Aneurysm, Abdominal"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T20:10:31.612445Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}