{"doi":"10.1093/eurjpc/zwac156","title":"Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis","abstract":"AIMS: The potential effect of alcohol consumption on coronary heart disease (CHD) remains unclear. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in subclinical and clinical CHD. METHODS: We conducted two Mendelian randomization studies: a cross-sectional study of coronary artery calcification (CAC) on computed tomography of 1029 healthy men (mean age, 63.8 years) and a case-control study of 421 men with CHD [acute coronary syndrome (ACS) or stable angina pectoris] who underwent coronary revascularization and 842 age-matched male controls. RESULTS: In the CAC study, medians (25%tiles, 75%tiles) of alcohol consumption by ALDH2-rs671 *2 homozygotes [n = 86 (8.4%)], *1*2 heterozygotes [n = 397 (38.5%)], and *1 homozygotes [n = 546 (53.1%)] were 0.0 (0.0, 0.0), 28.0 (0.0, 129.0), and 224.0 (84.0, 350.0) g/week, respectively. In age-adjusted Poisson regression with robust error variance, compared with *2 homozygotes, relative risks for prevalent CAC score >0, ≥100, and ≥300 in *1 homozygotes were 1.29 (95% confidence interval, 1.06-1.57), 1.76 (1.05-2.96), and 1.81 (0.80-4.09), respectively. In age-adjusted ordinal logistic regression for CAC distributions, we observed higher odds among *1 homozygotes [odds ratio, 2.19 (1.39-3.46)] and even among *1*2 heterozygotes [1.77 (1.11-2.82)] compared with *2 homozygotes. In the case-control study, conditional logistic regression revealed lower prevalence of *1 homozygotes among men with CHD [odds ratio, 0.54 (0.35-0.82)], especially ACS [0.46 (0.27-0.77)], than controls. CONCLUSION: Our findings indicate a positive association of alcohol consumption with CAC burden but an inverse association with clinical CHD, especially ACS.","journal":"European Journal of Preventive Cardiology","year":2022,"id":268721,"datarank":0.9307423924090837,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.47406402675057024,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.47406402675057024,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":15,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":37771,"name":"Katsuyuki Miura","orcid":"0000-0002-2646-9582","position":1,"is_corresponding":false},{"id":245390,"name":"Yasuharu Tabara","orcid":"0000-0003-4505-7951","position":2,"is_corresponding":false},{"id":930918,"name":"Yuichi Sawayama","orcid":"0000-0002-9409-0056","position":3,"is_corresponding":false},{"id":21645,"name":"Takashi Kadowaki","orcid":"0000-0002-5428-3582","position":4,"is_corresponding":false},{"id":318508,"name":"Aya Kadota","orcid":"0000-0001-7378-0544","position":5,"is_corresponding":false},{"id":930919,"name":"Sayuki Torii","orcid":"0000-0002-3104-9208","position":6,"is_corresponding":false},{"id":373796,"name":"Keiko Kondo","orcid":"0000-0002-9709-4474","position":7,"is_corresponding":false},{"id":22904,"name":"Yuichiro Yano","orcid":"0000-0002-2565-7290","position":8,"is_corresponding":false},{"id":373794,"name":"Akira Fujiyoshi","orcid":"0000-0002-5790-7119","position":9,"is_corresponding":false},{"id":92440,"name":"Takashi Yamamoto","orcid":"0000-0002-6516-2903","position":10,"is_corresponding":false},{"id":930920,"name":"Yoshihisa Nakagawa","orcid":"0000-0002-9411-9314","position":11,"is_corresponding":false},{"id":411764,"name":"Minoru Horie","orcid":"0000-0002-9029-2339","position":12,"is_corresponding":false},{"id":930921,"name":"Takeshi Kimura","orcid":"0000-0002-5665-4076","position":13,"is_corresponding":false},{"id":37773,"name":"Tomonori Okamura","orcid":"0000-0003-0488-0351","position":14,"is_corresponding":false},{"id":37772,"name":"Hirotsugu Ueshima","orcid":"0000-0002-7742-4253","position":15,"is_corresponding":false},{"id":373795,"name":"Takashi Hisamatsu","orcid":"0000-0002-6244-1763","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:14.088663Z","pmid":"35907253","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}