{"doi":"10.1093/emboj/19.14.3576","title":"Measles virus matrix protein specifies apical virus release and glycoprotein sorting in epithelial cells","abstract":null,"journal":"The EMBO Journal","year":2000,"id":645451,"datarank":0.7130385286659547,"base_score":4.7535901911063645,"endowment":4.7535901911063645,"self_citation_contribution":0.7130385286659547,"citation_network_contribution":0.0,"self_endowment_contribution":0.7130385286659547,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":115,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":596246,"name":"Elisabeth Ehler","orcid":"0000-0001-5646-5964","position":1,"is_corresponding":false},{"id":1680697,"name":"Martin A. Billeter","orcid":null,"position":2,"is_corresponding":false},{"id":1680696,"name":"Hussein Y. Naim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Measles virus matrix protein specifies apical virus release and glycoprotein sorting in epithelial cells","abstract":"In polarized epithelial cells measles virus (MV) is predominantly released at the apical cell surface, irrespective of the sorting of its two envelope glycoproteins F and H. It has been reported previously that the viral matrix (M) protein modulates the fusogenic capacity of the viral envelope glycoproteins. Here, extant MV mutants and chimeras were used to determine the role of M protein in the transport of viral glycoproteins and release of progeny virions in polarized epithelial CaCo2 cells. In the absence of M, envelope glycoproteins are sorted to the basolateral surface, suggesting that they possess intrinsic basolateral sorting signals. However, interactions of M with the glycoprotein cytoplasmic tails allow M-glycoprotein co-segregation to the apical surface, suggesting a vectorial function of M to retarget the glycoproteins for apical virion release. Whereas this may allow virus airway shedding, the intrinsic sorting of the glycoproteins to the basolateral surface may account for systemic host infection by allowing efficient cell-cell fusion.","is_dataset_classified":null,"base_score":4.7535901911063645,"endowment":4.7535901911063645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10899112","pmcid":"PMC313987","openalex_id":"https://openalex.org/W2035138045","authors":[],"funders":[{"funder_name":"Swiss National Science Foundation","grant_id":"52417","title":"Biogenesis of heart muscle cytoarchitecture"},{"funder_name":"Swiss National Science Foundation","grant_id":"45900","title":"Viral assembly, entry and pathogenesis: measles and measles chimeras"}],"total_grants":2,"fwci":6.5865,"citation_percentile":0.96983514,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":4},{"year":2014,"count":6},{"year":2015,"count":1},{"year":2016,"count":6},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/19.14.3576","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/19.14.3576","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Femboj%2F19.14.3576","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1093/emboj/19.14.3576.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1093/emboj/19.14.3576/fulltext.html","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full/10.1093/emboj/19.14.3576","host_type":"publisher"},{"url":"https://doi.org/10.1093/emboj/19.14.3576","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10899112","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/313987","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc313987?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1093/emboj/19.14.3576","host_type":""},{"url":"https://sonar.ch/global/documents/133069","host_type":""}],"fields_of_study":["Virology and Viral Diseases","Respiratory viral infections research","Animal Virus Infections Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Amino Acid Sequence","Animals","Cell Line","Epithelial Cells","Fluorescent Antibody Technique","Glycoproteins","Humans","Measles virus","Membrane Fusion","Molecular Sequence Data","Recombinant Fusion Proteins","Viral Fusion Proteins","Viral Matrix Proteins","Virus Replication","Cell Polarity","Sequence Deletion","Caco-2 Cells"],"keywords":["Glycoprotein","Biology","Measles virus","Viral matrix protein","Viral envelope","Cell biology","Sendai virus","Viral entry","Virus","Membrane glycoproteins","Mononegavirales","Herpesvirus glycoprotein B","Apical cell","Cell polarity","Vesicular stomatitis virus","Virology","Cell","Paramyxoviridae","Molecular biology","Viral replication","Biochemistry","Viral disease","General Immunology and Microbiology","General Neuroscience","Recombinant Fusion Proteins","Molecular Sequence Data","Fluorescent Antibody Technique","Epithelial Cells","Virus Replication","Membrane Fusion","General Biochemistry, Genetics and Molecular Biology","Cell Line","Viral Matrix Proteins","Animals","Humans","Amino Acid Sequence","Caco-2 Cells","Viral Fusion Proteins","Glycoproteins","Sequence Deletion"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:57:31.158885Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}