{"doi":"10.1093/emboj/16.12.3587","title":"The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein","abstract":null,"journal":"The EMBO Journal","year":1997,"id":622150,"datarank":0.8898367781172017,"base_score":5.932245187448011,"endowment":5.932245187448011,"self_citation_contribution":0.8898367781172017,"citation_network_contribution":0.0,"self_endowment_contribution":0.8898367781172017,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":376,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":18,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1606891,"name":"Paul S. Eder","orcid":null,"position":1,"is_corresponding":false},{"id":103469,"name":"Gideon Dreyfuss","orcid":"0000-0001-8129-8774","position":2,"is_corresponding":false},{"id":1606890,"name":"W.Matthew Michael","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein","abstract":"Protein import into the nucleus and export from the nucleus are signal-mediated processes that require energy. The nuclear transport process about which the most information is currently available is classical nuclear localization signal (NLS)-mediated nuclear import. However, details concerning the signal-mediated export of proteins and RNAs as well as alternative nuclear import pathways are beginning to emerge. An example of this is the heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein which, by virtue of its M9 domain, is actively exported from the nucleus and imported into the nucleus via a novel pathway mediated by the recently characterized transportin protein. Here we report that the shuttling hnRNP K protein contains a novel shuttling domain (termed KNS) which has many of the characteristics of M9, in that it confers bi-directional transport across the nuclear envelope. KNS-mediated nuclear import is dependent on RNA polymerase II transcription, and we show that a classical NLS can override this effect. Furthermore, KNS accesses a separate import pathway from either classical NLSs or M9. This demonstrates the existence of a third protein import pathway into the nucleus and thereby defines a new type of nuclear import/export 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Research and Splicing","Nuclear Structure and Function","Neurogenetic and Muscular Disorders Research","Amino Acid Sequence","Animals","Binding Sites","Cell Line","Cell Membrane Permeability","Cell Nucleus","Digitonin","HeLa Cells","Heterogeneous Nuclear Ribonucleoprotein A1","Heterogeneous-Nuclear Ribonucleoprotein Group A-B","Heterogeneous-Nuclear Ribonucleoprotein K","Heterogeneous-Nuclear Ribonucleoproteins","Humans","Molecular Sequence Data","Nuclear Localization Signals","Nuclear Proteins","Quail","Ribonucleoproteins","Xenopus"],"mesh_terms":["Heterogeneous Nuclear Ribonucleoprotein A1","Amino Acid Sequence","Animals","Binding Sites","Cell Line","Cell Membrane Permeability","Cell Nucleus","Digitonin","HeLa Cells","Humans","Molecular Sequence Data","Nuclear Proteins","Quail","Ribonucleoproteins","Xenopus","Nuclear Localization Signals","Heterogeneous-Nuclear Ribonucleoproteins","Heterogeneous-Nuclear Ribonucleoprotein Group A-B","Heterogeneous-Nuclear Ribonucleoprotein K","Hela Cells"],"keywords":["Nuclear transport","Nuclear export signal","Nuclear localization sequence","NLS","Heterogeneous nuclear ribonucleoprotein","Heterogeneous ribonucleoprotein particle","Biology","Cell biology","Ribonucleoprotein","Nuclear protein","Nucleoporin","Nuclear pore","Importin","Nucleus","Cell nucleus","Transcription factor","RNA","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.23983541.v1","title":"Additional file 9 of Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23983541","title":"Additional file 9 of Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23983352","title":"Additional file 6 of Keratin 19 binds and 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