{"doi":"10.1093/embo-reports/kve021","title":"The archaeal TFIIEα homologue facilitates transcription initiation by enhancing TATA‐box recognition","abstract":null,"journal":"The EMBO Reports","year":2001,"id":645406,"datarank":0.687745121800586,"base_score":4.584967478670572,"endowment":4.584967478670572,"self_citation_contribution":0.687745121800586,"citation_network_contribution":0.0,"self_endowment_contribution":0.687745121800586,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1680538,"name":"Arie B Brinkman","orcid":null,"position":1,"is_corresponding":false},{"id":165646,"name":"John van der Oost","orcid":null,"position":2,"is_corresponding":false},{"id":188636,"name":"Stephen P Jackson","orcid":null,"position":3,"is_corresponding":false},{"id":1680537,"name":"Stephen D Bell","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The archaeal TFIIEα homologue facilitates transcription initiation by enhancing TATA‐box recognition","abstract":"Transcription from many archaeal promoters can be reconstituted in vitro using recombinant TATA-box binding protein (TBP) and transcription factor B (TFB)--homologues of eukaryal TBP and TFIIB--together with purified RNA polymerase (RNAP). However, all archaeal genomes sequenced to date reveal the presence of TFE, a homologue of the alpha-subunit of the eukaryal general transcription factor, TFIIE. We show that, while TFE is not absolutely required for transcription in the reconstituted in vitro system, it nonetheless plays a stimulatory role on some promoters and under certain conditions. Mutagenesis of the TATA box or reduction of TBP concentration in transcription reactions sensitizes a promoter to TFE addition. Conversely, saturating reactions with TBP de-sensitizes promoters to TFE. These results suggest that TFE facilitates or stabilizes interactions between TBP and the TATA box.","is_dataset_classified":null,"base_score":4.584967478670572,"endowment":4.584967478670572,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11258705","pmcid":"PMC1083817","openalex_id":"https://openalex.org/W2121534706","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":3,"fwci":5.3874,"citation_percentile":0.96104871,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2026,"count":2}],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/embo-reports/kve021","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/embo-reports/kve021","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Fembo-reports%2Fkve021","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1093/embo-reports/kve021.pdf","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1093/embo-reports/kve021","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1093/embo-reports/kve021/fulltext.html","host_type":"publisher"},{"url":"https://www.embopress.org/doi/pdf/10.1093/embo-reports/kve021","host_type":"publisher"},{"url":"https://doi.org/10.1093/embo-reports/kve021","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11258705","host_type":"repository"},{"url":"https://research.wur.nl/en/publications/the-archaeal-tfiie-homologue-facilitates-transcription-initiation","host_type":"journal"},{"url":"http://europepmc.org/pmc/articles/PMC1083817","host_type":"repository"},{"url":"http://dx.doi.org/10.1093/embo-reports/kve021","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc1083817?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1093/embo-reports/kve021","host_type":""}],"fields_of_study":["Bacterial Genetics and Biotechnology","Genomics and Chromatin Dynamics","RNA and protein synthesis mechanisms","0301 basic medicine","0303 health sciences","03 medical and health sciences","Amino Acid Sequence","Archaeal Proteins","Base Sequence","DNA Footprinting","DNA-Binding Proteins","DNA-Directed RNA Polymerases","Deoxyribonuclease I","Molecular Sequence Data","Mutation","Protein Binding","Protein Subunits","Sequence Alignment","Sequence Homology, Amino Acid","Substrate Specificity","Sulfolobus","TATA Box","TATA-Box Binding Protein","Transcription Factors","Transcription Factors, TFII","Transcription, Genetic"],"mesh_terms":["Amino Acid Sequence","Base Sequence","Deoxyribonuclease I","DNA-Binding Proteins","Molecular Sequence Data","Mutation","Protein Binding","DNA-Directed RNA Polymerases","Substrate Specificity","Transcription Factors","Transcription, Genetic","TATA Box","Sequence Alignment","Sulfolobus","Sequence Homology, Amino Acid","DNA Footprinting","Transcription Factors, TFII","Archaeal Proteins","Protein Subunits","TATA-Box Binding Protein"],"keywords":["Transcription factor II A","Transcription factor II B","Promoter","TATA-Box Binding Protein","Transcription factor II E","TATA box","Transcription factor II D","General transcription factor","RNA polymerase II","Biology","Transcription (linguistics)","TAF2","Transcription factor","TATA-binding protein","Transcription factor II F","Transcription preinitiation complex","Molecular biology","Cell biology","Genetics","Gene","Gene expression","Base Sequence","Sequence Homology, Amino Acid","Transcription, Genetic","Archaeal Proteins","Molecular Sequence Data","DNA Footprinting","DNA-Directed RNA Polymerases","Substrate Specificity","Sulfolobus","DNA-Binding Proteins","Protein Subunits","Transcription Factors, TFII","Mutation","Life Science","Deoxyribonuclease I","Amino Acid Sequence","Sequence Alignment","Protein Binding","Transcription Factors"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:22:39.437224Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}