{"doi":"10.1093/ejendo/lvad087","title":"Oxytocin response to food intake in avoidant/restrictive food intake disorder","abstract":"OBJECTIVE: To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC). DESIGN: Cross-sectional. METHODS: A total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID. RESULTS: Participants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID. CONCLUSIONS: Consistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.","journal":"European Journal of Endocrinology","year":2023,"id":348134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8143,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513997,"name":"Maged Muhammed","orcid":null,"position":1,"is_corresponding":false},{"id":767776,"name":"Kendra R. Becker","orcid":"0000-0002-8946-9977","position":2,"is_corresponding":false},{"id":921090,"name":"Elisa Asanza","orcid":null,"position":3,"is_corresponding":false},{"id":1026620,"name":"Kristine Hauser","orcid":"0000-0001-7317-5440","position":4,"is_corresponding":false},{"id":1080174,"name":"Casey Stern","orcid":null,"position":5,"is_corresponding":false},{"id":1090376,"name":"Julia Gydus","orcid":"0000-0002-8407-1636","position":6,"is_corresponding":false},{"id":677305,"name":"Tara M. Holmes","orcid":"0000-0003-3613-6391","position":7,"is_corresponding":false},{"id":779199,"name":"Helen Burton Murray","orcid":"0000-0003-2059-3256","position":8,"is_corresponding":false},{"id":786917,"name":"Lauren Breithaupt","orcid":"0000-0002-2439-6519","position":9,"is_corresponding":false},{"id":399696,"name":"Nadia Micali","orcid":"0000-0001-5571-2273","position":10,"is_corresponding":false},{"id":388582,"name":"Madhusmita Misra","orcid":"0000-0002-9405-2981","position":11,"is_corresponding":false},{"id":706227,"name":"Kamryn T. Eddy","orcid":"0000-0002-1586-0930","position":12,"is_corresponding":false},{"id":767777,"name":"Jennifer J. Thomas","orcid":"0000-0003-2601-581X","position":13,"is_corresponding":false},{"id":640393,"name":"Elizabeth A. Lawson","orcid":"0000-0001-8619-3349","position":14,"is_corresponding":false},{"id":719191,"name":"Anna Aulinas","orcid":"0000-0002-1205-7114","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T01:12:06.040073Z","pmid":"37474111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}