{"doi":"10.1093/ehjqcco/qcaa015","title":"Association of post-diagnosis cardiorespiratory fitness with cause-specific mortality in cancer","abstract":"AIMS: The prognostic importance of post-diagnosis assessment of cardiorespiratory fitness (CRF) in cancer patients is not well established. We sought to examine the association between CRF and mortality in cancer patients. METHODS AND RESULTS: This was a single-centre cohort analysis of 1632 patients (58% male; 64 ± 12 years) with adult-onset cancer who were clinically referred for exercise treadmill testing a median of 7 [interquartile range (IQR): 3-12] years after primary diagnosis. Cardiorespiratory fitness was defined as peak metabolic equivalents (METs) achieved during standard Bruce protocol and categorized by tertiles. The association between CRF and all-cause and cause-specific mortality was assessed using multivariable Cox proportional hazard models adjusting for important covariates. Median follow-up was 4.6 (IQR: 2.6-7.0) years; a total of 411 deaths (229, 50, and 132 all-cause, cardiovascular (CV), and cancer related, respectively) occurred during this period. Compared with low CRF (range: 1.9-7.6 METs), the adjusted hazard ratio (HR) for all-cause mortality was 0.38 [95% confidence interval (CI): 0.28-0.52] for intermediate CRF (range: 7.7-10.6 METs) and 0.17 (95% CI: 0.11-0.27) for high CRF (range: 10.7-22.0 METs). The corresponding HRs were 0.40 (95% CI: 0.19-0.86) and 0.41 (95% CI: 0.16-1.05) for CV mortality and 0.40 (95% CI: 0.26-0.60) and 0.16 (95% CI: 0.09-0.28) for cancer mortality, respectively. The adjusted risk of all-cause, CV, and cancer mortality decreased by 26%, 14%, and 25%, respectively with each one MET increment in CRF. CONCLUSION: Cardiorespiratory fitness is a strong, independent predictor of all-cause, CV, and cancer mortality, even after adjustment for important clinical covariates in patients with certain cancers.","journal":"European Heart Journal - Quality of Care and Clinical Outcomes","year":2020,"id":56411,"datarank":0.6681520944380261,"base_score":4.454347296253507,"endowment":4.454347296253507,"self_citation_contribution":0.6681520944380261,"citation_network_contribution":0.0,"self_endowment_contribution":0.6681520944380261,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8983,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":293860,"name":"David Payne","orcid":null,"position":1,"is_corresponding":false},{"id":28286,"name":"Brian Claggett","orcid":"0000-0002-4215-9218","position":2,"is_corresponding":false},{"id":104010,"name":"Mandeep R. Mehra","orcid":"0000-0001-8683-7044","position":3,"is_corresponding":false},{"id":292885,"name":"Jingyi Gong","orcid":"0000-0001-7848-1084","position":4,"is_corresponding":false},{"id":293861,"name":"Jesse Caron","orcid":null,"position":5,"is_corresponding":false},{"id":232167,"name":"Syed Mahmood","orcid":"0000-0001-6938-1321","position":6,"is_corresponding":false},{"id":260672,"name":"Jon Hainer","orcid":"0000-0002-0572-912X","position":7,"is_corresponding":false},{"id":232198,"name":"Tomas G. Neilan","orcid":"0000-0002-1513-8833","position":8,"is_corresponding":false},{"id":292886,"name":"Ann H. Partridge","orcid":"0000-0002-4722-4824","position":9,"is_corresponding":false},{"id":260674,"name":"Marcelo F. Di Carli","orcid":"0000-0003-3119-025X","position":10,"is_corresponding":false},{"id":236656,"name":"Lee W. Jones","orcid":"0000-0002-3716-8793","position":11,"is_corresponding":false},{"id":232168,"name":"Anju Nohria","orcid":"0000-0002-7113-1118","position":12,"is_corresponding":false},{"id":232195,"name":"John D. Groarke","orcid":"0000-0002-5277-8696","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:05:49.581291Z","pmid":"32167560","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}