{"doi":"10.1093/ehjopen/oeaf069","title":"Glycolysis hijacked: a novel pathogenic role of lipoprotein(a) in valve disease","abstract":"Calcific aortic valve disease (CAVD), the most prevalent valve disease in the developed world, is characterized by progressive fibro-calcific remodeling of the valve cusps.Once symptomatic and left untreated, CAVD confers a dismal prognosis; with a 2-year mortality rate of 50% 1 .The only available treatment is surgical or transcatheter aortic valve replacement, primarily indicated in late-stage disease, imposing the unmet clinical need to uncover novel therapeutic targets to delay or countermand CAVD progression.The translation of novel targets into clinical trials for CAVD, however, is hampered by the largely unpredictable, lengthy, and pathophysiologically heterogenous progression from asymptomatic aortic valve sclerosis to symptomatic aortic stenosis (AS).","journal":"European Heart Journal Open","year":2025,"id":544635,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305056,"name":"Elena Aïkawa","orcid":"0000-0001-7835-2135","position":1,"is_corresponding":false},{"id":1173407,"name":"Luisa Weiß","orcid":"0000-0002-7018-5325","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:53:12.864581Z","pmid":"40654528","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}