{"doi":"10.1093/ehjcvp/pvae006","title":"Effects of albiglutide on myocardial infarction and ischaemic heart disease outcomes in patients with type 2 diabetes and cardiovascular disease in the Harmony Outcomes trial","abstract":"AIMS: Large outcome trials have demonstrated cardiovascular benefits of selected glucagon-like peptide-1 (GLP-1) receptor agonists. We examined coronary disease outcomes in the Harmony Outcomes trial of the GLP-1 receptor agonist albiglutide. METHODS AND RESULTS: Harmony Outcomes was an event-driven, multicenter, double-blind, and placebo-controlled trial involving 9463 patients >40 years of age with type-2 diabetes and established atherosclerotic cardiovascular disease. It tested the effects of albiglutide on the occurrence of a composite primary endpoint, consisting of cardiovascular death, myocardial infarction (MI), or stroke. Within this post-hoc analysis, the effects of albiglutide on MI subtypes and other ischaemic endpoints were analysed.During the median-follow up of 1.6 years, a total of 421 patients (4.5%) experienced at least one MI, with 72 patients having more than one event. Treatment with albiglutide reduced both first events [hazard ratio (HR) 0.75 (0.62-0.91)] and overall events [HR 0.75 (0.61-0.91)] as well as first type 1 [HR 0.73 (0.57-0.92)] and type 2 myocardial infarctions [HR 0.65 (0.46-0.92)]. The effect of albiglutide treatment was consistent for ST-segment elevation [HR 0.69 (0.38-1.26)] and non-ST elevation (HR 0.86 (0.66-1.2) MI. CONCLUSION: Treatment with the GLP-1 receptor agonist albiglutide resulted in a 25% relative risk reduction in MI that was consistent for type of infarction and presence or absence of ST elevation. Our findings add novel information about the effects of GLP-1 receptor agonists on ischaemic events in patients with type 2 diabetes.","journal":"European Heart Journal - Cardiovascular Pharmacotherapy","year":2024,"id":431887,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9347,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274454,"name":"Guillaume Marquis‐Gravel","orcid":"0000-0003-2965-1504","position":1,"is_corresponding":false},{"id":1236172,"name":"Shannon Murphy","orcid":"0009-0008-2085-3189","position":2,"is_corresponding":false},{"id":227162,"name":"Karen P. Alexander","orcid":"0000-0003-4418-1424","position":3,"is_corresponding":false},{"id":310753,"name":"Karen Chiswell","orcid":"0000-0002-0279-9093","position":4,"is_corresponding":false},{"id":276834,"name":"Jennifer B. Green","orcid":"0000-0002-9967-5352","position":5,"is_corresponding":false},{"id":276836,"name":"Lawrence A. Leiter","orcid":"0000-0002-1040-6229","position":6,"is_corresponding":false},{"id":55170,"name":"Renato D. Lópes","orcid":"0000-0003-2999-4961","position":7,"is_corresponding":false},{"id":40678,"name":"Stefano Del Prato","orcid":"0000-0002-5388-0270","position":8,"is_corresponding":false},{"id":302876,"name":"W. Schuyler Jones","orcid":"0000-0002-7288-9596","position":9,"is_corresponding":false},{"id":2612,"name":"John J.V. McMurray","orcid":"0000-0002-6317-3975","position":10,"is_corresponding":false},{"id":51666,"name":"Adrian F. Hernandez","orcid":"0000-0003-3387-9616","position":11,"is_corresponding":false},{"id":260564,"name":"Christopher B. Granger","orcid":"0000-0002-0045-3291","position":12,"is_corresponding":false},{"id":1043863,"name":"Konstantin A. Krychtiuk","orcid":"0000-0001-7792-2837","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:59:30.747263Z","pmid":"38271596","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}