{"doi":"10.1093/ehjcr/ytaa336","title":"Antiepileptic rufinamide and QTc interval shortening in a patient with long QT syndrome: case report","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>There is limited pharmacologic therapy to reduce the QT interval in hereditary long QT syndrome (LQTS).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary</jats:title>\n                  <jats:p>We describe a child with Allan–Herndon–Dudley syndrome, Lennox–Gastaut epileptic syndrome (LGS), and LQTS Type 1 (LQTS1). Rufinamide was added to his antiepileptic medications to improve seizure control and was noted to be associated with a marked improvement in electrocardiogram QT interval. To the best of our knowledge, this is the first reported case of successful pharmacologic shortening of the QT interval in LQTS1.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion</jats:title>\n                  <jats:p>This case report highlights the potential benefits of rufinamide, a drug associated with mild QT shortening in normal individuals, to markedly reduce and normalize QT duration in a subject with LQTS1.</jats:p>\n               </jats:sec>","journal":"European Heart Journal - Case Reports","year":2020,"id":594344,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420090,"name":"Kristen Sullivan","orcid":"0000-0002-0796-078X","position":1,"is_corresponding":false},{"id":1521414,"name":"Syam Divakaramenon","orcid":null,"position":2,"is_corresponding":false},{"id":891714,"name":"Robert M. Hamilton","orcid":"0000-0002-5344-1278","position":3,"is_corresponding":false},{"id":1060622,"name":"Tapas Mondal","orcid":"0000-0003-2077-1710","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Antiepileptic rufinamide and QTc interval shortening in a patient with long QT syndrome: case report","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>There is limited pharmacologic therapy to reduce the QT interval in hereditary long QT syndrome (LQTS).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary</jats:title>\n                  <jats:p>We describe a child with Allan–Herndon–Dudley syndrome, Lennox–Gastaut epileptic syndrome (LGS), and LQTS Type 1 (LQTS1). Rufinamide was added to his antiepileptic medications to improve seizure control and was noted to be associated with a marked improvement in electrocardiogram QT interval. To the best of our knowledge, this is the first reported case of successful pharmacologic shortening of the QT interval in LQTS1.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion</jats:title>\n                  <jats:p>This case report highlights the potential benefits of rufinamide, a drug associated with mild QT shortening in normal individuals, to markedly reduce and normalize QT duration in a subject with LQTS1.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33442618","pmcid":"PMC7793134","openalex_id":"https://openalex.org/W3106754853","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.25317433,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/ehjcr/article-pdf/4/6/1/35545576/ytaa336.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ehjcr/article-pdf/4/6/1/35545576/ytaa336.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/ehjcr/article-pdf/4/6/1/35545576/ytaa336.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ehjcr/ytaa336","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33442618","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC7793134","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7793134","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7793134","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7793134?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cardiac electrophysiology and arrhythmias","Takotsubo Cardiomyopathy and Associated Phenomena","Ion channel regulation and function"],"mesh_terms":[],"keywords":["QT interval","Long QT syndrome","Medicine","Short QT syndrome","Lennox–Gastaut syndrome","Epilepsy","Anesthesia","Internal medicine","Cardiology","Pediatrics","Psychiatry","Case Report","Rufinamide"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T14:21:18.420246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}