{"doi":"10.1093/ehjacc/zuac075","title":"Major adverse cardiovascular events after diagnosis of myocardial injury and types 1 and 2 myocardial infarction","abstract":"AIMS: Limited US outcome data exist among patients with myocardial injury and types 1 and 2 myocardial infarction (MI) evaluated with high-sensitivity cardiac troponin (hs-cTn). METHODS AND RESULTS: This is an observational US cohort study of emergency department (ED) patients undergoing hs-cTnT measurement. Cases with ≥1 hs-cTnT increase >99th percentile were adjudicated following the Fourth Universal Definition of MI. Post-discharge major adverse cardiovascular events (MACE) included death, MI, heart failure (HF) hospitalization, stroke or transient ischaemic attack, and new-onset atrial fibrillation or flutter during 2 years follow-up. Among 2002 patients, 857 (43%) had ≥1 hs-cTnT >99th percentile. Among these, 702 (81.9%) had myocardial injury, 64 (7.5%) had type 1 MI, and 91 (10.6%) had type 2 MI. Compared with patients without myocardial injury, type 2 MI [8.4 vs. 50%; adjusted hazard ratio (HR) 2.31, 95% confidence interval (CI) 1.49-3.58] and myocardial injury (8.4 vs. 47%; adjusted HR 3.13, 95% CI 2.39-4.09) had a higher risk of MACE, in large part because of death and HF hospitalizations. Compared with patients with type 1 MI, type 2 MI (23 vs. 50%; adjusted HR 2.24; 95% CI 1.23-4.10) and myocardial injury (23 vs. 47%; adjusted HR 2.02; 95% CI 1.20-3.40) also have a higher risk of MACE. CONCLUSION: Among unselected US ED patients undergoing hs-cTnT measurement, most increases are due to myocardial injury, and type 2 MI is more frequent than type 1 MI. Patients with myocardial injury and type 2 MI have morbid outcomes, in large part due to death and HF.","journal":"European Heart Journal Acute Cardiovascular Care","year":2022,"id":270934,"datarank":0.4559616256833985,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.06010302624110955,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.06010302624110955,"corpus_percentile":58.55960392975942,"corpus_rank":5358,"citation_count":13,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5643,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":653218,"name":"Olatunde Ola","orcid":"0000-0001-5230-7037","position":1,"is_corresponding":false},{"id":653220,"name":"Laura De Michieli","orcid":"0000-0003-0574-4052","position":2,"is_corresponding":false},{"id":653219,"name":"Ashok Akula","orcid":"0000-0002-1840-0999","position":3,"is_corresponding":false},{"id":377106,"name":"Ramila A. Mehta","orcid":"0000-0003-3769-3173","position":4,"is_corresponding":false},{"id":653221,"name":"Marshall Dworak","orcid":"0000-0001-6847-2416","position":5,"is_corresponding":false},{"id":654221,"name":"Erika Crockford","orcid":null,"position":6,"is_corresponding":false},{"id":653222,"name":"Ronstan Lobo","orcid":"0000-0003-2674-4334","position":7,"is_corresponding":false},{"id":654222,"name":"Nicholas Rastas","orcid":null,"position":8,"is_corresponding":false},{"id":654223,"name":"Swetha Karturi","orcid":null,"position":9,"is_corresponding":false},{"id":654224,"name":"Scott Wohlrab","orcid":null,"position":10,"is_corresponding":false},{"id":287453,"name":"David O. Hodge","orcid":null,"position":11,"is_corresponding":false},{"id":653224,"name":"Eric Grube","orcid":"0000-0002-5954-1261","position":12,"is_corresponding":false},{"id":653225,"name":"Tahir Tak","orcid":"0000-0002-8703-5745","position":13,"is_corresponding":false},{"id":228981,"name":"Charles Cagin","orcid":"0000-0002-3054-6448","position":14,"is_corresponding":false},{"id":355743,"name":"Rajiv Gulati","orcid":"0000-0002-2713-0433","position":15,"is_corresponding":false},{"id":302756,"name":"Allan S. Jaffe","orcid":"0000-0003-1183-3959","position":16,"is_corresponding":false},{"id":653226,"name":"Yader Sandoval","orcid":"0000-0003-4800-2972","position":17,"is_corresponding":false},{"id":653223,"name":"Jonathan D Knott","orcid":"0000-0002-2331-1165","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"35715942","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}