{"doi":"10.1093/eep/dvae017","title":"Bronchial cell epigenetic aging in a human experimental study of short-term diesel and ozone exposures","abstract":"Abstract Blood-based, observational, and cross-sectional epidemiological studies suggest that air pollutant exposures alter biological aging. In a single-blinded randomized crossover human experiment of 17 volunteers, we examined the effect of randomized 2-h controlled air pollution exposures on respiratory tissue epigenetic aging. Bronchial epithelial cell DNA methylation 24 h post-exposure was measured using the HumanMethylation450K BeadChip, and there was a minimum 2-week washout period between exposures. All 17 volunteers were exposed to ozone, but only 13 were exposed to diesel exhaust. Horvath DNAmAge [Pearson coefficient (r) = 0.64; median absolute error (MAE) = 2.7 years], GrimAge (r = 0.81; MAE = 13 years), and DNAm Telomere Length (DNAmTL) (r = −0.65) were strongly correlated with chronological age in this tissue. Compared to clean air, ozone exposure was associated with longer DNAmTL (median difference 0.11 kb, Fisher’s exact P-value = .036). This randomized trial suggests a weak relationship of ozone exposure with DNAmTL in target respiratory cells. Still, causal relationships with long-term exposures need to be evaluated.","journal":"Current Zoology","year":2024,"id":477581,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338908,"name":"Anne K. Bozack","orcid":"0000-0003-0046-5767","position":1,"is_corresponding":false},{"id":334851,"name":"Cavin Ward‐Caviness","orcid":"0000-0002-6322-4349","position":2,"is_corresponding":false},{"id":377680,"name":"David Díaz-Sánchez","orcid":null,"position":3,"is_corresponding":false},{"id":376439,"name":"Robert B. Devlin","orcid":"0000-0002-8510-2000","position":4,"is_corresponding":false},{"id":344879,"name":"Marie‐Abèle Bind","orcid":"0000-0002-0422-6651","position":5,"is_corresponding":false},{"id":274134,"name":"Andrés Cárdenas","orcid":"0000-0003-2284-3298","position":6,"is_corresponding":false},{"id":352866,"name":"Jamaji C. Nwanaji‐Enwerem","orcid":"0000-0003-0356-4867","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:06:37.812633Z","pmid":"39416749","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}