{"doi":"10.1093/ecco-jcc/jjad186","title":"Clinical Predictors of Early and Late Endoscopic Recurrence Following Ileocolonic Resection in Crohn’s Disease","abstract":"BACKGROUND AND AIMS: Multiple factors are suggested to place Crohn's disease patients at risk of recurrence after ileocolic resection with conflicting associations. We aimed to identify clinical predictors of recurrence at first [early] and further [late] postoperative colonoscopy. METHODS: Crohn's disease patients undergoing ileocolic resection were prospectively recruited at six North American centres. Clinical data were collected and endoscopic recurrence was defined as Rutgeerts score ≥i2. A multivariable model was fitted to analyse variables independently associated with recurrence. RESULTS: A total of 365 patients undergoing 674 postoperative colonoscopies were included with a median age of 32 years, 189 [51.8%] were male, and 37 [10.1%] were non-Whites. Postoperatively, 133 [36.4%] used anti-tumour necrosis factor [anti-TNF] and 30 [8.2%] were smokers. At first colonoscopy, 109 [29.9%] had recurrence. Male gender (odds ratio [OR] = 1.95, 95% confidence interval [CI] 1.12-3.40), non-White ethnicity [OR = 2.48, 95% CI 1.09-5.63], longer interval between surgery and colonoscopy [OR = 1.09, 95% CI 1.002-1.18], and postoperative smoking [OR = 2.78, 95% CI 1.16-6.67] were associated with recurrence, while prophylactic anti-TNF reduced the risk [OR = 0.28, 95% CI 0.14-0.55]. Postoperative anti-TNF prophylaxis had a protective effect on anti-TNF experienced patients but not on anti-TNF naïve patients. Among patients without recurrence at first colonoscopy, Rutgeerts score i1 was associated with subsequent recurrence [OR = 4.43, 95% CI 1.73-11.35]. CONCLUSIONS: We identified independent clinical predictors of early and late Crohn's disease postoperative endoscopic recurrence. Clinical factors traditionally used for risk stratification failed to predict recurrence and need to be revised.","journal":"Journal of Crohn s and Colitis","year":2023,"id":327835,"datarank":0.8095742537525168,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.3151987238518674,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.3151987238518674,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":17,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9264,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672597,"name":"Margaret Walshe","orcid":"0000-0002-8696-354X","position":1,"is_corresponding":false},{"id":1049224,"name":"Sondra Birch","orcid":null,"position":2,"is_corresponding":false},{"id":583024,"name":"Ksenija Sabic","orcid":null,"position":3,"is_corresponding":false},{"id":290519,"name":"Ujunwa Korie","orcid":null,"position":4,"is_corresponding":false},{"id":289526,"name":"Colleen Chasteau","orcid":"0009-0004-4985-1567","position":5,"is_corresponding":false},{"id":1049225,"name":"Vessela Miladinova","orcid":null,"position":6,"is_corresponding":false},{"id":1049226,"name":"William B Sabol","orcid":null,"position":7,"is_corresponding":false},{"id":414153,"name":"Emebet Mengesha","orcid":"0000-0001-7830-1557","position":8,"is_corresponding":false},{"id":1048644,"name":"Mary Hanna","orcid":"0009-0001-6838-1263","position":9,"is_corresponding":false},{"id":954186,"name":"Valeriya Pozdnyakova","orcid":"0000-0003-0764-0038","position":10,"is_corresponding":false},{"id":549761,"name":"Lisa W. Datta","orcid":null,"position":11,"is_corresponding":false},{"id":685435,"name":"Rita Kohen","orcid":"0000-0002-0119-3321","position":12,"is_corresponding":false},{"id":1049227,"name":"Raquel Milgrom","orcid":null,"position":13,"is_corresponding":false},{"id":747544,"name":"Joanne M. Stempak","orcid":"0009-0001-6510-8608","position":14,"is_corresponding":false},{"id":685434,"name":"Alain Bitton","orcid":"0000-0001-7214-1978","position":15,"is_corresponding":false},{"id":289527,"name":"Steven R. Brant","orcid":"0000-0003-3019-4240","position":16,"is_corresponding":false},{"id":1108,"name":"John D. Rioux","orcid":"0000-0001-7560-8326","position":17,"is_corresponding":false},{"id":1090,"name":"Dermot McGovern","orcid":"0000-0001-5621-759X","position":18,"is_corresponding":false},{"id":279534,"name":"Richard H. Duerr","orcid":"0000-0001-6586-3905","position":19,"is_corresponding":false},{"id":105285,"name":"Judy H. Cho","orcid":"0000-0002-7959-0466","position":20,"is_corresponding":false},{"id":353456,"name":"L. Philip Schumm","orcid":"0000-0002-3050-2429","position":21,"is_corresponding":false},{"id":250799,"name":"Mark S. Silverberg","orcid":"0000-0002-9534-1419","position":22,"is_corresponding":false},{"id":668152,"name":"Mark Lazarev","orcid":"0000-0002-5517-3588","position":23,"is_corresponding":false},{"id":672599,"name":"Cristian Hernández-Rocha","orcid":"0000-0001-9018-4242","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:08:47.581262Z","pmid":"37976264","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}