{"doi":"10.1093/ecco-jcc/jjad145","title":"Short-term Psychodynamic Psychotherapy in Addition to Standard Medical Therapy Increases Clinical Remission in Adolescents and Young Adults with Inflammatory Bowel Disease: a Randomised Controlled Trial","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Inflammatory bowel diseases [IBD] are chronic and pervasive conditions of the gastrointestinal tract with a rising incidence in paediatric and young adult populations. Evidence suggests that psychological disorders might be associated with relapse of disease activity. This study aims to evaluate the efficacy of short-term psychodynamic psychotherapy [STPP] in addition to standard medical therapy [SMT] in maintaining clinical remission in adolescents and young adults [AYA] with quiescent IBD, compared with SMT alone.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>A two-arm, single-centre, randomised, controlled trial was conducted in 60 IBD AYA in clinical remission. Patients were randomised to receive an 8-week STPP + SMT [n = 30] or SMT alone [n = 30]. The primary outcome was the steroid-free remission rate at 52 weeks after treatment. Secondary outcomes included the overall hospitalisation rate within 52 weeks after treatment, and medication adherence obtained from patient’s electronic medical records.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Intention-to-treat analysis showed significant improvement in maintaining disease remission rates in the 8-week STPP + SMT group compared with the control one. The proportion of patients maintaining steroid-free remission at 52 weeks was higher in patients in STTP group [93.1%] compared with patients randomised to control group [64.3%; p = 0.01]. There were no significant differences in secondary outcomes, except for depression reduction in STPP + SMT group.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>An 8-week STPP intervention in addition to SMT effectively increases the steroid-free remission rates in AYA with quiescent IBD. Results do not support effects for other secondary outcomes, except for depression reduction.</jats:p>\n               </jats:sec>","journal":"Journal of Crohn's and Colitis","year":2024,"id":611854,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1575070,"name":"Chiara Imondi","orcid":null,"position":1,"is_corresponding":false},{"id":1575071,"name":"Carmen D’Amore","orcid":null,"position":2,"is_corresponding":false},{"id":1575073,"name":"Giulia Angelino","orcid":null,"position":3,"is_corresponding":false},{"id":1575074,"name":"Daniela Knafelz","orcid":null,"position":4,"is_corresponding":false},{"id":1575076,"name":"Fiammetta Bracci","orcid":null,"position":5,"is_corresponding":false},{"id":1048935,"name":"Luigi Dall’Oglio","orcid":"0000-0002-7677-5086","position":6,"is_corresponding":false},{"id":1130572,"name":"Paola De Angelis","orcid":null,"position":7,"is_corresponding":false},{"id":1575078,"name":"Paola Tabarini","orcid":null,"position":8,"is_corresponding":false},{"id":1575069,"name":"Francesco Milo","orcid":"0000-0003-2746-4086","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Short-term Psychodynamic Psychotherapy in Addition to Standard Medical Therapy Increases Clinical Remission in Adolescents and Young Adults with Inflammatory Bowel Disease: a Randomised Controlled Trial","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Inflammatory bowel diseases [IBD] are chronic and pervasive conditions of the gastrointestinal tract with a rising incidence in paediatric and young adult populations. Evidence suggests that psychological disorders might be associated with relapse of disease activity. This study aims to evaluate the efficacy of short-term psychodynamic psychotherapy [STPP] in addition to standard medical therapy [SMT] in maintaining clinical remission in adolescents and young adults [AYA] with quiescent IBD, compared with SMT alone.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>A two-arm, single-centre, randomised, controlled trial was conducted in 60 IBD AYA in clinical remission. Patients were randomised to receive an 8-week STPP + SMT [n = 30] or SMT alone [n = 30]. The primary outcome was the steroid-free remission rate at 52 weeks after treatment. Secondary outcomes included the overall hospitalisation rate within 52 weeks after treatment, and medication adherence obtained from patient’s electronic medical records.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Intention-to-treat analysis showed significant improvement in maintaining disease remission rates in the 8-week STPP + SMT group compared with the control one. The proportion of patients maintaining steroid-free remission at 52 weeks was higher in patients in STTP group [93.1%] compared with patients randomised to control group [64.3%; p = 0.01]. There were no significant differences in secondary outcomes, except for depression reduction in STPP + SMT group.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>An 8-week STPP intervention in addition to SMT effectively increases the steroid-free remission rates in AYA with quiescent IBD. Results do not support effects for other secondary outcomes, except for depression reduction.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37621051","pmcid":null,"openalex_id":"https://openalex.org/W4386152296","authors":[],"funders":[{"funder_name":"Italian Ministry of Health","grant_id":"","title":null}],"total_grants":1,"fwci":3.4624,"citation_percentile":0.93337867,"influential_citations":0,"citation_trend":[{"year":2024,"count":5},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjad145/51246130/jjad145.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjad145/51246130/jjad145.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjad145/51800817/jjad145.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/ecco-jcc/article-pdf/18/2/256/56759525/jjad145.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ecco-jcc/jjad145","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37621051","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10896630","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10896630/pdf/jjad145.pdf","host_type":"repository"}],"fields_of_study":["Inflammatory Bowel Disease","Gastrointestinal motility and disorders","Adolescent and Pediatric Healthcare","Humans","Young Adult","Adolescent","Child","Psychotherapy, Psychodynamic","Inflammatory Bowel Diseases","Mental Disorders"],"mesh_terms":["Adolescent","Mental Disorders","Child","Humans","Inflammatory Bowel Diseases","Young Adult","Psychotherapy, Psychodynamic"],"keywords":["Medicine","Randomized controlled trial","Depression (economics)","Internal medicine","Clinical trial","Incidence (geometry)","Young adult","Pediatrics","Psychotherapy","effectiveness","paediatric","randomised controlled trial"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T23:19:40.679235Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}