{"doi":"10.1093/ecco-jcc/jjad056","title":"Inflammatory Bowel Disease and Risk of Colorectal Polyps: A Nationwide Population-Based Cohort Study From Sweden","abstract":"BACKGROUND: Inflammatory bowel disease [IBD] has been linked to an increased risk of colorectal neoplasia. However, the types and risks of specific polyp types in IBD are less clear. METHODS: We identified 41 880 individuals with IBD (Crohn's disease [CD: n = 12 850]; ulcerative colitis [UC]: n = 29 030]) from Sweden matched with 41 880 reference individuals. Using Cox regression, we calculated adjusted hazard ratios [aHRs] for neoplastic colorectal polyps [tubular, serrated/sessile, advanced and villous] defined by histopathology codes. RESULTS: During follow-up, 1648 [3.9%] IBD patients and 1143 [2.7%] reference individuals had an incident neoplastic colorectal polyp, corresponding to an incidence rate of 46.1 and 34.2 per 10 000 person-years, respectively. This correlated to an aHR of 1.23 (95% confidence interval [CI] 1.12-1.35) with the highest HRs seen for sessile serrated polyps [8.50, 95% CI 1.10-65.90] and traditional serrated adenomas [1.72, 95% CI 1.02-2.91]. aHRs for colorectal polyps were particularly elevated in those diagnosed with IBD at a young age and at 10 years after diagnosis. Both absolute and relative risks of colorectal polyps were higher in UC than in CD [aHRs 1.31 vs 1.06, respectively], with a 20-year cumulative risk difference of 4.4% in UC and 1.5% in CD, corresponding to one extra polyp in 23 patients with UC and one in 67 CD patients during the first 20 years after IBD diagnosis. CONCLUSIONS: In this nationwide population-based study, there was an increased risk of neoplastic colorectal polyps in IBD patients. Colonoscopic surveillance in IBD appears important, especially in UC and after 10 years of disease.","journal":"Journal of Crohn s and Colitis","year":2023,"id":372471,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240157,"name":"Ola Olén","orcid":"0000-0002-5478-7019","position":1,"is_corresponding":false},{"id":463188,"name":"Jonas Söderling","orcid":"0000-0001-9006-2835","position":2,"is_corresponding":false},{"id":109511,"name":"Björn Roelstraete","orcid":"0009-0002-1634-7415","position":3,"is_corresponding":false},{"id":51740,"name":"Hamed Khalili","orcid":"0000-0002-7956-6941","position":4,"is_corresponding":false},{"id":104568,"name":"Mingyang Song","orcid":"0000-0002-1324-0316","position":5,"is_corresponding":false},{"id":451432,"name":"Adam S. Faye","orcid":"0000-0002-1571-5856","position":6,"is_corresponding":false},{"id":1132793,"name":"Michael Eberhardson","orcid":"0000-0003-1052-7108","position":7,"is_corresponding":false},{"id":240783,"name":"Jonas Halfvarson","orcid":"0000-0003-0122-7234","position":8,"is_corresponding":false},{"id":109513,"name":"Jonas F. Ludvigsson","orcid":"0000-0003-1024-5602","position":9,"is_corresponding":false},{"id":345072,"name":"Jordan E. Axelrad","orcid":"0000-0003-1951-7790","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:15:54.000926Z","pmid":"36994851","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}