{"doi":"10.1093/ecco-jcc/jjac167","title":"Intake of Ultra-processed Foods Is Associated with an Increased Risk of Crohn’s Disease: A Cross-sectional and Prospective Analysis of 187 154 Participants in the UK Biobank","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims</jats:title>\n                  <jats:p>Ultra-processed food [UPF] consumption has been linked to globally increasing incidence and prevalence of chronic diseases, including inflammatory bowel diseases [IBD]. We aimed to investigate the association between UPF consumption and IBD incidence, prevalence, and IBD-relevant outcomes.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>We performed a cross-sectional and prospective cohort study in 187 854 individuals included in the national UK Biobank, using 24-h dietary recall questionnaires. Multivariable logistic regression and Cox proportional hazard regression were used to examine the association between UPFs and the prevalence and incidence risk of IBD, respectively.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>A total of 185 849 participants with a mean age of 56.2 were included, with a mean follow-up of 9.84 years. During follow-up, 841 developed IBD (251 Crohn’s disease [CD], and 590 ulcerative colitis [UC]). UPF intake in IBD patients was significantly higher: CD: odds ratio [OR] 1.94 (95% confidence interval [CI]: 1.52, 2.49, p &amp;lt;0.001); UC: OR 1.39 [95% CI: 1.17, 1.65, p &amp;lt;0.001]. Compared with low consumption, higher UPF consumption was significantly associated with incident CD: hazard ration [HR] 2.00 [95% CI: 1.32, 3.03, p = 0.001], but not UC. We also found a significant association between UPF intake and need of IBD-related surgery: HR 4.06 [95% CI: 1.52, 10.86, p = 0.005].</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion</jats:title>\n                  <jats:p>Higher intake of UPFs was associated with higher incidence of CD, but not UC. In individuals with a pre-existing diagnosis of IBD, consumption of UPFs was significantly higher compared with controls, and was associated with an increased need for IBD-related surgery. Further studies are needed to address the impact of UPF intake on disease pathogenesis and outcomes.</jats:p>\n               </jats:sec>","journal":"Journal of Crohn's and Colitis","year":2023,"id":634905,"datarank":0.7091081728068512,"base_score":4.727387818712341,"endowment":4.727387818712341,"self_citation_contribution":0.7091081728068512,"citation_network_contribution":0.0,"self_endowment_contribution":0.7091081728068512,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":112,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":755813,"name":"Judith Wellens","orcid":"0000-0002-1647-8151","position":1,"is_corresponding":false},{"id":1646935,"name":"Rahul Kalla","orcid":"0000-0002-3276-6751","position":2,"is_corresponding":false},{"id":435266,"name":"Tian Fu","orcid":null,"position":3,"is_corresponding":false},{"id":97781,"name":"Minzi Deng","orcid":"0000-0003-0464-4578","position":4,"is_corresponding":false},{"id":6714,"name":"Han Zhang","orcid":"0000-0002-9991-9409","position":5,"is_corresponding":false},{"id":995692,"name":"Shuai Yuan","orcid":"0000-0001-5055-5627","position":6,"is_corresponding":false},{"id":447637,"name":"Xiaoyan Wang","orcid":"0009-0002-1735-7148","position":7,"is_corresponding":false},{"id":1575876,"name":"Evropi Theodoratou","orcid":null,"position":8,"is_corresponding":false},{"id":913388,"name":"Xue Li","orcid":"0000-0001-7073-7532","position":9,"is_corresponding":false},{"id":589866,"name":"Jack Satsangi","orcid":null,"position":10,"is_corresponding":false},{"id":942377,"name":"Jie Chen","orcid":"0000-0002-4029-4192","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-06T14:20:34.336026Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}