{"doi":"10.1093/database/bav025","title":"SCAN database: facilitating integrative analyses of cytosine modification and expression QTL","abstract":null,"journal":"Database","year":2015,"id":624546,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":59.6,"corpus_rank":5391,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":609514,"name":"E. R. Gamazon","orcid":null,"position":1,"is_corresponding":false},{"id":1298896,"name":"X. Zhang","orcid":"0000-0002-8256-9721","position":2,"is_corresponding":false},{"id":1614526,"name":"A. Konkashbaev","orcid":null,"position":3,"is_corresponding":false},{"id":1324788,"name":"C. Liu","orcid":"0009-0002-2689-974X","position":4,"is_corresponding":false},{"id":1614527,"name":"K. L. Szilagyi","orcid":null,"position":5,"is_corresponding":false},{"id":527653,"name":"M. E. Dolan","orcid":null,"position":6,"is_corresponding":false},{"id":609507,"name":"N. J. Cox","orcid":null,"position":7,"is_corresponding":false},{"id":706308,"name":"W. Zhang","orcid":"0009-0003-7137-7294","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SCAN database: facilitating integrative analyses of cytosine modification and expression QTL","abstract":"Functional annotation of genetic variants including single nucleotide polymorphisms (SNPs) and copy number variations (CNV) promises to greatly improve our understanding of human complex traits. Previous transcriptomic studies involving individuals from different global populations have investigated the genetic architecture of gene expression variation by mapping expression quantitative trait loci (eQTL). Functional interpretation of genome-wide association studies (GWAS) has identified enrichment of eQTL in top signals from GWAS of human complex traits. The SCAN (SNP and CNV Annotation) database was developed as a web-based resource of genetical genomic studies including eQTL detected in the HapMap lymphoblastoid cell line samples derived from apparently healthy individuals of European and African ancestry. Considering the critical roles of epigenetic gene regulation, cytosine modification quantitative trait loci (mQTL) are expected to add a crucial layer of annotation to existing functional genomic information. Here, we describe the new features of the SCAN database that integrate comprehensive mQTL mapping results generated in the HapMap CEU (Caucasian residents from Utah, USA) and YRI (Yoruba people from Ibadan, Nigeria) LCL samples and demonstrate the utility of the enhanced functional annotation system.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25818895","pmcid":"PMC4375357","openalex_id":"https://openalex.org/W2165696350","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL084715","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"R21 HG006367","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"U01 GM61393","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P60 DK20595","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH090937","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P60 DK020595","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH101820","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"U01 GM061393","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000430","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK020595","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P50 CA125183","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01MH090937-01","title":"Using the Transcriptome for SNP and Gene Annotation"},{"funder_name":"National Institutes of Health","grant_id":"5P50CA125183-04","title":"Variation in Hormone and xenobiotic metabolizing enzyme genes and breast cancer"},{"funder_name":"National Institutes of Health","grant_id":"1R21HG006367-01","title":"Epigenetic and Genetic Dissection of Drug Response"},{"funder_name":"National Institutes of Health","grant_id":"1U01HL084715-01","title":"Genome-wide Association Mapping of Metabolic, Lung and Cardiovascular Phenotypes"},{"funder_name":"National Institutes of Health","grant_id":"5P60DK020595-24","title":"CORE--RADIOIMMUNOASSAY AND CLINICAL STUDIES LABORATORY"},{"funder_name":"National Institutes of Health","grant_id":"3U01GM061393-10S1","title":"Pharmacogenetics of Anticancer Agents Research Group"}],"total_grants":17,"fwci":2.4762,"citation_percentile":0.89778673,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2023,"count":2},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav025/7298636/bav025.pdf","host_type":"journal"},{"url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav025/7298636/bav025.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/database/article-pdf/doi/10.1093/database/bav025/7298636/bav025.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/database/bav025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25818895","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/80f2e27f-e300-4f51-889f-cb8bb217dd81","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/scan-database-facilitating-integrative-analyses-of-cytosine-modification-and-expression-qtl(f6b03f38-5f0b-4aac-8ed3-77693b6a564e).html","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4375357","host_type":"repository"},{"url":"https://figshare.com/articles/journal_contribution/SCAN_database_facilitating_integrative_analyses_of_cytosine_modification_and_expression_QTL_/10760402","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/files/160684053/Scan-database-facilitating-integrative-analyses-of-cytosine-modification-and-expression-qtl.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4375357","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4375357?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/database/bav025","host_type":""},{"url":"https://dx.doi.org/10.1093/database/bav025","host_type":""}],"fields_of_study":["Genetic Associations and Epidemiology","Epigenetics and DNA Methylation","Genomic variations and chromosomal abnormalities","0301 basic medicine","0303 health sciences","03 medical and health sciences","Black People","Cytosine","Databases, Nucleic Acid","Gene Expression Regulation","Humans","Polymorphism, Single Nucleotide","Quantitative Trait Loci","Transcriptome","White People"],"mesh_terms":["Cytosine","Gene Expression Regulation","Humans","Polymorphism, Single Nucleotide","Databases, Nucleic Acid","Quantitative Trait Loci","Black People","White People","Transcriptome"],"keywords":["International HapMap Project","Expression quantitative trait loci","Quantitative trait locus","Genome-wide association study","Single-nucleotide polymorphism","Biology","Genetics","Genetic association","Computational biology","dbSNP","Annotation","Human genome","Genome","Gene","Genotype","Quantitative Trait Loci","Black People","Polymorphism, Single Nucleotide","White People","Cytosine","Gene Expression Regulation","Database Update","Humans","Databases, Nucleic Acid","Transcriptome"],"sdg_mappings":[{"sdg_number":13,"sdg_label":"13. Climate action"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"refsnp"},{"name":"igsr"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T04:05:39.943061Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}