{"doi":"10.1093/database/baab037","title":"KMDATA: a curated database of reconstructed individual patient-level data from 153 oncology clinical trials","abstract":"We created a database of reconstructed patient-level data from published clinical trials that includes multiple time-to-event outcomes such as overall survival and progression-free survival. Outcomes were extracted from Kaplan-Meier (KM) curves reported in 153 oncology Phase III clinical trial publications identified through a PubMed search of clinical trials in breast, lung, prostate and colorectal cancer, published between 2014 and 2016. For each trial that met our search criteria, we curated study-level information and digitized all reported KM curves with the software Digitizelt. We then used the digitized KM survival curves to estimate (possibly censored) patient-level time-to-event outcomes. Collections of time-to-event datasets from completed trials can be used to support the choice of appropriate trial designs for future clinical studies. Patient-level data allow investigators to tailor clinical trial designs to diseases and classes of treatments. Patient-level data also allow investigators to estimate the operating characteristics (e.g. power and type I error rate) of candidate statistical designs and methods. Database URL: https://10.6084/m9.figshare.14642247.v1.","journal":"Database","year":2021,"id":204384,"datarank":0.36860269332976536,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.12718700646465028,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.12718700646465028,"corpus_percentile":51.35762357855651,"corpus_rank":6289,"citation_count":4,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9426,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.14642247.v1"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":250460,"name":"Robert Redd","orcid":"0000-0002-1329-5288","position":1,"is_corresponding":false},{"id":786674,"name":"Alyssa M. Vanderbeek","orcid":"0000-0002-3278-5071","position":2,"is_corresponding":false},{"id":642613,"name":"Rifaquat Rahman","orcid":"0000-0002-9443-1797","position":3,"is_corresponding":false},{"id":642614,"name":"Bill Louv","orcid":"0000-0002-2789-4994","position":4,"is_corresponding":false},{"id":643694,"name":"Jon McDunn","orcid":null,"position":5,"is_corresponding":false},{"id":786675,"name":"Andrea Arfè","orcid":"0000-0003-1534-0609","position":6,"is_corresponding":false},{"id":7893,"name":"Brian M. Alexander","orcid":"0000-0003-3903-9175","position":7,"is_corresponding":false},{"id":29956,"name":"Steffen Ventz","orcid":"0000-0003-2229-9560","position":8,"is_corresponding":false},{"id":250470,"name":"Lorenzo Trippa","orcid":"0000-0001-5218-5666","position":9,"is_corresponding":false},{"id":786673,"name":"Geoffrey Fell","orcid":"0000-0001-6436-6691","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:51:26.121843Z","pmid":"34169314","pmcid":"PMC8234134","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}