{"doi":"10.1093/cvr/cvu082.91","title":"P153MicroRNAs involved in cardioprotection by ischemic pre- and postconditioning: ProtectomiRs","abstract":null,"journal":"Cardiovascular Research","year":2014,"id":658029,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1717740,"name":"A Zvara","orcid":null,"position":1,"is_corresponding":false},{"id":1717742,"name":"N Farago","orcid":null,"position":2,"is_corresponding":false},{"id":1717744,"name":"M Pipicz","orcid":null,"position":3,"is_corresponding":false},{"id":1717746,"name":"R Gaspar","orcid":null,"position":4,"is_corresponding":false},{"id":1717748,"name":"A Gorbe","orcid":null,"position":5,"is_corresponding":false},{"id":1717749,"name":"GL Puskas","orcid":null,"position":6,"is_corresponding":false},{"id":1717750,"name":"T Csont","orcid":null,"position":7,"is_corresponding":false},{"id":1717751,"name":"T Thum","orcid":null,"position":8,"is_corresponding":false},{"id":1717752,"name":"P Ferdinandy","orcid":null,"position":9,"is_corresponding":false},{"id":1717739,"name":"ZV Varga","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"P153MicroRNAs involved in cardioprotection by ischemic pre- and postconditioning: ProtectomiRs","abstract":"Purpose: We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Methods: Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic perfusion, ii) ischemia/reperfusion (30 min coronary occlusion and 120 min reperfusion), iii) preconditioning (3x5 min coronary occlusion) followed by ischemia/reperfusion, or iv) ischemia/reperfusion with postconditioning (6x10s global ischemia/reperfusion at the onset of reperfusion, respectively. Infarct size was significantly reduced by both interventions. Results: Out of 350 different microRNAs assessed by microarray analysis, 147-160 showed detectable expression levels. As compared to microRNA alterations induced by ischemia/reperfusion vs. time-matched non-ischemic controls, 5 microRNAs were significantly affected by both pre- and postconditioning (microRNA-125b*, 139-3p, 320, 532-3p, 188), 4 microRNAs by preconditioning (microRNA-487b, 139-5p, 192, 212), and 9 by postconditioning (microRNA-1, let-7i, let-7e, let7b, 181a, 208, 328, 335, 503), respectively. Expression of randomly selected microRNAs was validated by QRT-PCR. By a systematic comparison of the direction of microRNA expression changes in all groups, we identified microRNAs, specific mimics or antagomiRs of which may have pre- and postconditioning-like cardioprotective effect (protectomiRs). Transfection of selected protectomiRs (mimics of microRNA-139-5p, -125b*, and let-7b) into cardiac myocytes subjected to simulated ischemia/reperfusion showed significant cytoprotective effect. Conclusions: This is the first demonstration that ischemia/reperfusion-induced microRNA expression profile is significantly influenced by both pre- and postconditioning, which shows the involvement of microRNAs in cardioprotective signaling. Moreover, by analysis of microRNA expression patterns in cardioprotection by pre- and postconditioning, specific protectomiRs can be revealed as potential therapeutic tools treating ischemia/reperfusion injury.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19965766","pmcid":null,"openalex_id":"https://openalex.org/W2161218770","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.16555998,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/cardiovascres/article-pdf/103/suppl_1/S27/5094880/cvu082.91.pdf","host_type":"journal"},{"url":"https://academic.oup.com/cardiovascres/article-pdf/103/suppl_1/S27/5094880/cvu082.91.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/cardiovascres/article-pdf/103/suppl_1/S27/5094880/cvu082.91.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/cvr/cvu082.91","host_type":"journal"}],"fields_of_study":["Cardiac Ischemia and Reperfusion","Anesthesia and Neurotoxicity Research","Mitochondrial Function and Pathology"],"mesh_terms":[],"keywords":["Cardioprotection","Medicine","Cardiology","Ischemia","Internal medicine","microRNA","Myocardial Reperfusion Injury","Myocardial ischemia","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T03:04:56.699282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}