{"doi":"10.1093/cvr/cvr042","title":"Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation","abstract":null,"journal":"Cardiovascular Research","year":2011,"id":684069,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1787094,"name":"Changping Hu","orcid":null,"position":1,"is_corresponding":false},{"id":1585151,"name":"Qiong Yuan","orcid":null,"position":2,"is_corresponding":false},{"id":263725,"name":"Tianlun Yang","orcid":"0000-0001-9835-1279","position":3,"is_corresponding":false},{"id":31799,"name":"Jun Peng","orcid":"0000-0003-2401-731X","position":4,"is_corresponding":false},{"id":1787095,"name":"Yuanjian Li","orcid":null,"position":5,"is_corresponding":false},{"id":1152182,"name":"Yongping Bai","orcid":"0000-0002-6355-5842","position":6,"is_corresponding":false},{"id":1787096,"name":"Zehong Cao","orcid":null,"position":7,"is_corresponding":false},{"id":1787097,"name":"Guangjie Cheng","orcid":null,"position":8,"is_corresponding":false},{"id":342886,"name":"Guogang Zhang","orcid":"0000-0002-4353-0234","position":9,"is_corresponding":false},{"id":1455859,"name":"Ruizheng Shi","orcid":"0000-0002-1537-4430","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation","abstract":"AIMS: Vascular peroxidase 1 (VPO1) is a newly identified haem-containing peroxidase that catalyses the oxidation of a variety of substrates by hydrogen peroxide (H(2)O(2)). Considering the well-defined effects of H(2)O(2) on the vascular remodelling during hypertension, and that VPO1 can utilize H(2)O(2) generated from co-expressed NADPH oxidases to catalyse peroxidative reactions, the aims of this study were to determine the potential role of VPO1 in vascular remodelling during hypertension. METHODS AND RESULTS: The vascular morphology and the expression of VPO1 in arterial tissues of spontaneously hypertensive rats and Wistar-Kyoto rats were assessed. The VPO1 expression was significantly increased concomitantly with definite vascular remodelling assessed by evaluating the media thickness, lumen diameter, media thickness-to-lumen diameter ratio and mean nuclear area in artery media in spontaneously hypertensive rats. In addition, in cultured rat aortic smooth muscle cells we found that the angiotensin II-mediated cell proliferation was inhibited by knockdown of VPO1 using small hairpin RNA. Moreover, the NADPH oxidase inhibitor, apocynin, and the hydrogen peroxide scavenger, catalase, but not the ERK1/2 inhibitor, PD98059, attenuated angiotensin II-mediated up-regulation of VPO1 and generation of hypochlorous acid. CONCLUSION: VPO1 is a novel regulator of vascular smooth muscle cell proliferation via NADPH oxidase-H(2)O(2)-VPO1-hypochlorous acid-ERK1/2 pathways, which may contribute to vascular remodelling in hypertension.","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21292788","pmcid":"PMC3112017","openalex_id":"https://openalex.org/W2119982842","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL086836","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL086836","title":null}],"total_grants":2,"fwci":3.3097,"citation_percentile":0.92811528,"influential_citations":0,"citation_trend":[{"year":2012,"count":19},{"year":2013,"count":5},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":6},{"year":2017,"count":9},{"year":2018,"count":7},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://academic.oup.com/cardiovascres/article-pdf/91/1/27/17392176/cvr042.pdf","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3112017","host_type":"repository"},{"url":"http://academic.oup.com/cardiovascres/article-pdf/91/1/27/17392176/cvr042.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/cvr/cvr042","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21292788","host_type":"repository"}],"fields_of_study":["Neutrophil, Myeloperoxidase and Oxidative Mechanisms","Nitric Oxide and Endothelin Effects","Vanadium and Halogenation Chemistry","Analysis of Variance","Angiotensin II","Animals","Aorta, Thoracic","Cell Proliferation","Cells, Cultured","Disease Models, Animal","Enzyme Activation","Enzyme Inhibitors","Extracellular Matrix Proteins","Free Radical Scavengers","Hydrogen Peroxide","Hypertension","Hypochlorous Acid","Male","Mesenteric Arteries","Mitogen-Activated Protein Kinase 1","Mitogen-Activated Protein Kinase 3","Muscle, Smooth, Vascular","Myocytes, Smooth Muscle","NADPH Oxidases","Peroxidase","RNA Interference","RNA, Messenger","Rats","Rats, Inbred SHR","Rats, Inbred WKY","Signal Transduction","Time Factors","Peroxidasin"],"mesh_terms":["Peroxidasin","Analysis of Variance","Angiotensin II","Animals","Aorta, Thoracic","Cells, Cultured","Disease Models, Animal","Enzyme Activation","Enzyme Inhibitors","Hydrogen Peroxide","Hypertension","Hypochlorous Acid","Male","Mesenteric Arteries","Muscle, Smooth, Vascular","Peroxidase","Rats, Inbred SHR","Rats, Inbred WKY","RNA, Messenger","Time Factors","Signal Transduction","Free Radical Scavengers","Extracellular Matrix Proteins","NADPH Oxidases","Mitogen-Activated Protein Kinase 1","Myocytes, Smooth Muscle","RNA Interference","Mitogen-Activated Protein Kinase 3","Cell Proliferation","Rats"],"keywords":["Vascular smooth muscle","Angiotensin II","Peroxidase","Renin–angiotensin system","Internal medicine","Endocrinology","Cell growth","Medicine","Chemistry","Cell biology","Biology","Smooth muscle","Enzyme","Biochemistry","Receptor","Blood pressure"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:13:27.284333Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}