{"doi":"10.1093/cvr/cvp089","title":"Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet","abstract":null,"journal":"Cardiovascular Research","year":2009,"id":682347,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1782645,"name":"Gregor Muller","orcid":null,"position":1,"is_corresponding":false},{"id":1782646,"name":"Anja Leuner","orcid":null,"position":2,"is_corresponding":false},{"id":373798,"name":"Tatsuya Sawamura","orcid":"0000-0002-5415-2080","position":3,"is_corresponding":false},{"id":1782647,"name":"Ursula Ravens","orcid":null,"position":4,"is_corresponding":false},{"id":185803,"name":"Henning Morawietz","orcid":"0000-0001-9360-9736","position":5,"is_corresponding":false},{"id":1782644,"name":"Birgit Eichhorn","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet","abstract":"AIMS: LOX-1 is a major vascular receptor for oxidized low-density lipoprotein (oxLDL). In this study, we analysed the impact of LOX-1 overexpression and high dietary fat intake on vascular function in small resistance arteries. METHODS AND RESULTS: Relaxation of mesenteric arteries was measured using a wire myograph. Compared with the control group, mice overexpressing LOX-1 on a high-fat diet (FD) had preserved vascular smooth muscle relaxation, but impaired endothelium-dependent relaxation via NO. Vascular NO availability was decreased by exaggerated formation of reactive oxygen species and decreased endothelial NO synthase expression. Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation via cytochrome P450 metabolites was increased in LOX-1 + FD animals, but did not completely compensate for the loss of NO. Currents of calcium-activated potassium channels with large conductance (BKCa channels) were measured by the voltage-clamp method. The BKCa current amplitudes were not altered in endothelial cells, but highly increased in vascular smooth muscle cells from resistance arteries of LOX-1-overexpressing mice on FD. BK(Ca) currents were activated by low-dose H2O2 and cytochrome P450 metabolites 11,12-EET and 14,15-EET as EDHF in control mice. CONCLUSION: LOX-1 overexpression and FD caused functional changes in endothelial and vascular smooth muscle cells of small resistance arteries.","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19289377","pmcid":null,"openalex_id":"https://openalex.org/W2099467808","authors":[],"funders":[],"total_grants":0,"fwci":1.0974,"citation_percentile":0.77774095,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":6},{"year":2019,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://academic.oup.com/cardiovascres/article-pdf/82/3/493/17391277/cvp089.pdf","host_type":"BRONZE"},{"url":"http://academic.oup.com/cardiovascres/article-pdf/82/3/493/17391277/cvp089.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/cvr/cvp089","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19289377","host_type":"repository"}],"fields_of_study":["Atherosclerosis and Cardiovascular Diseases","Nitric Oxide and Endothelin Effects","Inflammatory mediators and NSAID effects","Medicine","Biology","Environmental Science"],"mesh_terms":["Animals","Body Weight","Cattle","Diet, Atherogenic","Dietary Fats","Lipids","Male","Mesenteric Arteries","Mice, Inbred C57BL","RNA, Messenger","Vascular Resistance","Reactive Oxygen Species","Large-Conductance Calcium-Activated Potassium Channels","Scavenger Receptors, Class E","Mice","Nitric Oxide Synthase Type III"],"keywords":["Myograph","Mesenteric arteries","Endocrinology","Internal medicine","Vascular smooth muscle","Electrical impedance myography","Endothelium","Chemistry","Vasodilation","Biology","Medicine","Artery"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:10:23.045152Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}