{"doi":"10.1093/ckj/sfaf138","title":"Global, regional and national epidemiology of anemia attributable to chronic kidney disease, 1990–2021","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Chronic kidney disease (CKD) presents a significant global health challenge, with anemia frequently manifesting in the more advanced stages. This study aimed to evaluate the global burden and cross-country inequality of CKD-related anemia from 1990 to 2021.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Data on CKD-related anemia were extracted from the Global Burden of Disease 2021 study. Trends in prevalence, years lived with disability (YLDs) and corresponding estimated annual percentage changes (EAPCs) from 1990 to 2021 were analyzed at global, regional and national levels. Health inequity analysis methodologies were employed to evaluate cross-country inequality based on sociodemographic index.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>In 2021, global CKD-related anemia cases reached 63 751 624 [95% uncertainty interval (UI), 59 045 051–68 372 650], representing a 96.24% increase from 1990 (32 486 224; 95% UI 30 356 876–35 047 084). Notwithstanding this increase, global prevalence [EAPC –0.27; 95% confidence interval (CI) –0.34 to –0.21] and YLDs rates (EAPC –0.66; 95% CI –0.70 to –0.62) generally declined. Females were disproportionately affected, comprising 55.75% of prevalence cases and 65.87% of YLDs numbers in 2021. From 1990 to 2021, the burden increased in individuals with CKD-related anemia associated with type 1 diabetes. Significant cross-country inequalities in prevalence were observed and persisted [slope index of inequality: 255.04 (389.56–120.51) in 1990 to 423.30 (572.78–273.81) in 2021; health concentration index: –0.09 (–0.12 to –0.07) in 1990 to –0.14 (–0.17 to –0.11) in 2021].</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Despite the global decline in prevalence and YLDs rates of CKD-related anemia, the number of cases continued to increase, and the burden disproportionately concentrated in less developed countries and territories. This investigation also revealed a gender disparity and the influence of specific causes.</jats:p>\n               </jats:sec>","journal":"Clinical Kidney Journal","year":2025,"id":634242,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644813,"name":"Wenhua Gu","orcid":null,"position":1,"is_corresponding":false},{"id":926536,"name":"Junhui Chen","orcid":"0000-0002-7085-0022","position":2,"is_corresponding":false},{"id":232298,"name":"Ruobing Wang","orcid":"0000-0003-0277-8329","position":3,"is_corresponding":false},{"id":1644816,"name":"Yaohua Shen","orcid":null,"position":4,"is_corresponding":false},{"id":1644817,"name":"Zhaoyu Lu","orcid":null,"position":5,"is_corresponding":false},{"id":989319,"name":"Lei Zhang","orcid":"0000-0001-5301-4658","position":6,"is_corresponding":false},{"id":434203,"name":"Wenli Liu","orcid":"0000-0003-1036-4564","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Global, regional and national epidemiology of anemia attributable to chronic kidney disease, 1990–2021","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Chronic kidney disease (CKD) presents a significant global health challenge, with anemia frequently manifesting in the more advanced stages. This study aimed to evaluate the global burden and cross-country inequality of CKD-related anemia from 1990 to 2021.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Data on CKD-related anemia were extracted from the Global Burden of Disease 2021 study. Trends in prevalence, years lived with disability (YLDs) and corresponding estimated annual percentage changes (EAPCs) from 1990 to 2021 were analyzed at global, regional and national levels. Health inequity analysis methodologies were employed to evaluate cross-country inequality based on sociodemographic index.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>In 2021, global CKD-related anemia cases reached 63 751 624 [95% uncertainty interval (UI), 59 045 051–68 372 650], representing a 96.24% increase from 1990 (32 486 224; 95% UI 30 356 876–35 047 084). Notwithstanding this increase, global prevalence [EAPC –0.27; 95% confidence interval (CI) –0.34 to –0.21] and YLDs rates (EAPC –0.66; 95% CI –0.70 to –0.62) generally declined. Females were disproportionately affected, comprising 55.75% of prevalence cases and 65.87% of YLDs numbers in 2021. From 1990 to 2021, the burden increased in individuals with CKD-related anemia associated with type 1 diabetes. Significant cross-country inequalities in prevalence were observed and persisted [slope index of inequality: 255.04 (389.56–120.51) in 1990 to 423.30 (572.78–273.81) in 2021; health concentration index: –0.09 (–0.12 to –0.07) in 1990 to –0.14 (–0.17 to –0.11) in 2021].</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Despite the global decline in prevalence and YLDs rates of CKD-related anemia, the number of cases continued to increase, and the burden disproportionately concentrated in less developed countries and territories. This investigation also revealed a gender disparity and the influence of specific causes.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40421272","pmcid":"PMC12104806","openalex_id":"https://openalex.org/W4410484480","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82174308","title":null},{"funder_name":"Natural Science Research Project of Guangdong Province","grant_id":"2024Al515011955","title":null},{"funder_name":"Project of Guangzhou Basic and Applied Basic Research Foundation","grant_id":"2023A03J0743","title":null},{"funder_name":"Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine","grant_id":"SZ2023ZZ03","title":null},{"funder_name":"Guangzhou City-school-enterprise joint funding project","grant_id":"SL2023A03J00958","title":null},{"funder_name":"Guangzhou Science and Technology Project","grant_id":"202206010076","title":null}],"total_grants":6,"fwci":3.3381,"citation_percentile":0.9216757,"influential_citations":0,"citation_trend":[{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfaf138/63236767/sfaf138.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfaf138/63236767/sfaf138.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ckj/sfaf138","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40421272","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12104806","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12104806","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12104806?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Erythropoietin and Anemia Treatment","Chronic Kidney Disease and Diabetes","Iron Metabolism and Disorders"],"mesh_terms":[],"keywords":["Epidemiology","Kidney disease","Medicine","Disease","Anemia","Environmental health","Intensive care medicine","Internal medicine","Chronic Kidney Disease","Health Inequalities","disease burden","Estimated Annual % Changes"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:22:47.724711Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}