{"doi":"10.1093/ckj/sfaf069","title":"Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial","abstract":"ABSTRACT Background Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited progressive kidney disease. Time-restricted eating (TRE) is a fasting regimen that restricts eating to a particular window (typically 8 hours/day), which could slow cyst growth based on preclinical models. Methods A 12-month, randomized, controlled, behavioral dietary intervention compared TRE with a control group given healthy eating advice without TRE (HE), without caloric restriction. Participants underwent baseline and 12-month measurements, including adherence (percentage of participants adhering to the 8-hour window; primary outcome), and MRI to determine height-adjusted total kidney volume (htTKV) and adiposity. Results Twenty-nine participants (23 females, mean standard ± deviation 48 ± 9 years) with a body mass index of 31.1±5 kg/m2 were randomized to TRE (n = 14) or HE (n = 15). Of the total participants, 71% (n = 10) of TRE and 87% (n = 13) of HE participants completed the intervention. The eating window was 9.6 ± 3.6 hours for TRE (60% achieving the 8-hour window) and 12.0 ± 2.0 for HE groups (P = .07). At month 12, both groups lost modest weight (−2.4 ± 6.4% and −3.6 ± 5.4% in the TRE and HE groups, respectively). Annual change in htTKV was 3.0 ± 8.5% and 4.6 ± 8.8% in the TRE and HE groups, respectively. Both change in weight (r = 0.67, P < .01) and change in visceral adiposity (r = 0.54, P < .01) were positively correlated with change in htTKV. Conclusion Both the TRE and HE group lost modest weight at 12 months. The targeted TRE adherence of ≥75% of participants was not achieved. Weight and adiposity loss may be more important drivers of kidney growth than the timing of eating.","journal":"Clinical Kidney Journal","year":2025,"id":522817,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1266555,"name":"Anna Ostrow","orcid":null,"position":1,"is_corresponding":false},{"id":542407,"name":"Wei Wang","orcid":"0000-0002-1430-1360","position":2,"is_corresponding":false},{"id":1395341,"name":"Erin R. Coleman","orcid":null,"position":3,"is_corresponding":false},{"id":410700,"name":"Diana George","orcid":null,"position":4,"is_corresponding":false},{"id":662542,"name":"Kristen Bing","orcid":null,"position":5,"is_corresponding":false},{"id":1395342,"name":"Sumana Ramanathan","orcid":null,"position":6,"is_corresponding":false},{"id":286368,"name":"Adriana Gregory","orcid":"0000-0001-9760-5302","position":7,"is_corresponding":false},{"id":409881,"name":"Berenice Y. Gitomer","orcid":"0000-0002-7457-6497","position":8,"is_corresponding":false},{"id":328678,"name":"Timothy L. Kline","orcid":"0000-0002-7917-9853","position":9,"is_corresponding":false},{"id":321351,"name":"Elizabeth A. Thomas","orcid":"0000-0003-1137-6516","position":10,"is_corresponding":false},{"id":110793,"name":"Michel Chonchol","orcid":null,"position":11,"is_corresponding":false},{"id":409878,"name":"Kristen L. Nowak","orcid":"0000-0001-9364-3256","position":12,"is_corresponding":false},{"id":665243,"name":"Cortney Steele","orcid":"0000-0002-5701-1240","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:49:58.707747Z","pmid":"40207097","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}