{"doi":"10.1093/cid/ciaf026","title":"Ongoing Symptoms After Acute SARS-CoV-2 or Influenza Infection in a Case-Ascertained Household Transmission Study: 7 US Sites, 2021–2023","abstract":"BACKGROUND: The prevalence and risk factors for ongoing symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [SCV2]) or influenza infection are not well characterized. We conducted a prospective cohort study of households wherein ≥1 individual was infected with SCV2 or influenza to evaluate prevalence of and factors associated with ongoing symptoms at 90 days. METHODS: Index cases and their household contacts provided baseline health and sociodemographic information and collected daily respiratory specimens for 10 days following enrollment. Participants completed a follow-up survey 90 days after enrollment to characterize ongoing symptoms. RESULTS: We analyzed 1967 participants enrolled between December 2021 and May 2023. The risk of ongoing symptoms did not differ by infection status in SCV2 (SCV2-positive: 15.6%; SCV2-negative: 13.9%; odds ratio [OR]: 1.14; 95% CI: .7-1.69) or influenza (influenza-positive: 8.8%; influenza-negative: 10.0%; OR: .87; 95% CI: .45-1.72) households. However, among study participants with a documented infection, SCV2-positive participants had nearly twice the odds of ongoing symptoms as influenza-positive participants (OR: 1.92; 95% CI: 1.27-2.97). CONCLUSIONS: These results suggest that SCV2 households have a significantly higher prevalence of ongoing symptoms compared with influenza households (OR: 1.78; 95% CI: 1.28-2.47). Among participants with SCV2 infection, underlying conditions (adjusted OR [aOR]: 2.65; 95% CI: 1.80-3.90) and coronavirus disease 2019 (COVID-19)-like symptoms (aOR: 2.92; 95% CI: 1.15-7.43) during acute infection increased odds of ongoing symptoms at 90 days, whereas hybrid immunity reduced the odds of ongoing symptoms (aOR: 0.44; 95% CI: .22-.90).","journal":"Clinical Infectious Diseases","year":2025,"id":532036,"datarank":0.21996813587157452,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.012023981703590886,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.012023981703590886,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":611844,"name":"Alexandra F. 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Asturias","orcid":"0000-0002-1275-0787","position":7,"is_corresponding":false},{"id":667678,"name":"Karen Lutrick","orcid":"0000-0003-3480-849X","position":8,"is_corresponding":false},{"id":667694,"name":"Katherine Ellingson","orcid":"0000-0001-7624-312X","position":9,"is_corresponding":false},{"id":50477,"name":"Yvonne Maldonado","orcid":"0000-0002-5664-5583","position":10,"is_corresponding":false},{"id":320361,"name":"Alexandra M. Mellis","orcid":"0000-0001-6756-1425","position":11,"is_corresponding":false},{"id":797882,"name":"Sarah E. Smith-Jeffcoat","orcid":"0000-0002-7962-9017","position":12,"is_corresponding":false},{"id":105907,"name":"Carlos G. Grijalva","orcid":"0000-0002-2329-7797","position":13,"is_corresponding":false},{"id":105916,"name":"H. Keipp Talbot","orcid":"0000-0003-0141-1760","position":14,"is_corresponding":false},{"id":105908,"name":"Melissa A. Rolfes","orcid":"0000-0002-0483-9941","position":15,"is_corresponding":false},{"id":808180,"name":"Jessica E. Deyoe","orcid":"0000-0001-6702-8698","position":16,"is_corresponding":false},{"id":105909,"name":"Yuwei Zhu","orcid":"0000-0001-9849-1634","position":17,"is_corresponding":false},{"id":1040804,"name":"Karla Ledezma","orcid":null,"position":18,"is_corresponding":false},{"id":1040805,"name":"Kathleen Pryor","orcid":null,"position":19,"is_corresponding":false},{"id":1237223,"name":"Ana Valdez de Romero","orcid":null,"position":20,"is_corresponding":false},{"id":826516,"name":"Celibell Vargas","orcid":"0000-0002-7518-5738","position":21,"is_corresponding":false},{"id":335129,"name":"Joshua G. Petrie","orcid":"0000-0002-5696-965X","position":22,"is_corresponding":false},{"id":536072,"name":"Michelle Floris-Moore","orcid":null,"position":23,"is_corresponding":false},{"id":86554,"name":"Natalie M. 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