{"doi":"10.1093/cid/ciae474","title":"Short and Long-term Body Weight Change Following the Switch to or the Addition of Integrase Inhibitors in Persons With HIV Differs by Sex","abstract":"BACKGROUND: Sex-specific, long-term, body weight change in persons with human immunodeficiency virus (PWH) following switch to regimens containing integrase strand transfer inhibitors (INSTIs) is unknown. METHODS: We compared PWH enrolled in the MACS/WIHS Combined Cohort Study (2007-2020) who switched/added an INSTI to their antiretroviral therapy (ART) regimen to those remaining on non-INSTI ART and to people without human immunodeficiency virus (PWOH), by sex. Follow-up time was time since switch visit (or comparable visit in controls). Linear regression mixed-effects models assessed the effects of sex, group, and time upon weight and anthropometric measurements. RESULTS: Of 3464 participants included, women (411 INSTI, 709 non-INSTI, 818 PWOH) compared to men (223 INSTI, 412 non-INSTI, 891 PWOH) were younger (47.2 vs 54.5 years), were majority non-Hispanic Black (65% vs 23%), and had higher mean body mass index (31.5 vs 26.9 kg/m2), respectively. Women switching to INSTIs experienced greater absolute and percentage weight gain compared to men at 5 years: +3.0 kg (95% confidence interval [CI], 2.1-3.9) versus +1.8 kg (95% CI, .7-2.9) and +4.6% (95% CI, 3.5%-5.7%) versus +2.3% (95% CI, 1.0%-3.6%), respectively ([sex × time × group interaction, P < .01). Compared to men, women switching to INSTIs experienced greater hip and thigh circumference gain at 5 years: +2.6 cm (95% CI, 1.6-3.6) versus +1.2 cm (95% CI, .3-2.1) and +1.5 cm (95% CI, .7-2.2) versus -0.2 cm (95% CI, -.9 to .5), respectively. CONCLUSIONS: Weight change among PWH over 5 years after switch to INSTI was 2-fold higher in women than men. The cardiometabolic implications of this difference in weight gain remain unknown.","journal":"Clinical Infectious Diseases","year":2024,"id":439099,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9362,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":303362,"name":"C Christina Mehta","orcid":null,"position":1,"is_corresponding":false},{"id":1249693,"name":"Qian Yang","orcid":"0000-0001-5986-2682","position":2,"is_corresponding":false},{"id":1250369,"name":"Tsungirirai Maramba","orcid":null,"position":3,"is_corresponding":false},{"id":1250370,"name":"Joffi Musonge-Effoe","orcid":null,"position":4,"is_corresponding":false},{"id":1249694,"name":"Chin-An Yang","orcid":"0000-0003-0232-794X","position":5,"is_corresponding":false},{"id":536629,"name":"Julie B. Dumond","orcid":"0000-0002-3500-5819","position":6,"is_corresponding":false},{"id":409544,"name":"María L. Alcaide","orcid":"0000-0003-4648-0145","position":7,"is_corresponding":false},{"id":240258,"name":"Jordan E. Lake","orcid":"0000-0002-0640-5514","position":8,"is_corresponding":false},{"id":259565,"name":"Leah H. Rubin","orcid":"0000-0003-2749-6328","position":9,"is_corresponding":false},{"id":301950,"name":"Audrey L. French","orcid":"0000-0002-9776-8934","position":10,"is_corresponding":false},{"id":329433,"name":"Jennifer Cocohoba","orcid":"0000-0003-4003-1939","position":11,"is_corresponding":false},{"id":69682,"name":"Seble Kassaye","orcid":"0000-0002-7527-7384","position":12,"is_corresponding":false},{"id":375965,"name":"Anjali Sharma","orcid":"0000-0002-8189-0732","position":13,"is_corresponding":false},{"id":240241,"name":"Frank J. Palella","orcid":"0000-0002-2277-6841","position":14,"is_corresponding":false},{"id":258969,"name":"John W. Mellors","orcid":"0000-0002-3737-9742","position":15,"is_corresponding":false},{"id":404729,"name":"Deborah Konkle‐Parker","orcid":"0000-0002-3319-8442","position":16,"is_corresponding":false},{"id":1075131,"name":"Elizabeth Topper","orcid":null,"position":17,"is_corresponding":false},{"id":602391,"name":"Michael Augenbraun","orcid":"0000-0002-8277-2850","position":18,"is_corresponding":false},{"id":22946,"name":"Mohammed K. Ali","orcid":"0000-0001-7266-2503","position":19,"is_corresponding":false},{"id":301948,"name":"Anandi N. Sheth","orcid":"0000-0002-6305-2727","position":20,"is_corresponding":false},{"id":320518,"name":"Thomas R. Ziegler","orcid":"0000-0001-9329-1481","position":21,"is_corresponding":false},{"id":382869,"name":"Igho Ofotokun","orcid":"0000-0003-2735-1903","position":22,"is_corresponding":false},{"id":279559,"name":"Jessica A. Alvarez","orcid":"0000-0002-7612-1162","position":23,"is_corresponding":false},{"id":690554,"name":"Cecile D. Lahiri","orcid":"0000-0002-5605-8266","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:47.992543Z","pmid":"39324701","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}