{"doi":"10.1093/cid/ciae406","title":"Integrase Strand Transfer Inhibitor–Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium","abstract":"BACKGROUND: With integrase strand transfer inhibitor (INSTI) use associated with increased body mass index (BMI) and BMI increases associated with higher diabetes mellitus (DM) risk, we explored the relationships between INSTI/non-INSTI regimens, BMI changes, and DM risk. METHODS: RESPOND participants were included if they had CD4, human immunodeficiency virus (HIV) RNA, and ≥2 BMI measurements during follow-up. Those with prior DM were excluded. DM was defined as a random blood glucose ≥11.1 mmol/L, hemoglobin A1c ≥6.5%/48 mmol/mol, use of antidiabetic medication, or site-reported clinical diagnosis. Poisson regression was used to assess the association between natural log (ln) of time-updated BMI and current INSTI/non-INSTI and their interactions on DM risk. RESULTS: Among 20 865 people with HIV included, most were male (74%) and White (73%). Baseline median age was 45 years (interquartile range [IQR], 37-52), with a median BMI of 24 kg/m2 (IQR, 22-26). There were 785 DM diagnoses with a crude rate of 0.73 (95% confidence interval [CI], .68-.78)/100 person-years of follow-up. ln(BMI) was strongly associated with DM (adjusted incidence rate ratio [aIRR], 16.54 per log increase; 95% CI, 11.33-24.13; P < .001). Current INSTI use was associated with increased DM risk (IRR, 1.58; 95% CI, 1.37-1.82; P < .001) in univariate analyses and only partially attenuated when adjusted for variables including ln(BMI) (aIRR, 1.48; 95% CI, 1.29-1.71; P < .001). There were no interactions between ln(BMI), INSTI, and non-INSTI use and DM (P = .130). CONCLUSIONS: In RESPOND, compared with non-INSTIs, current use of INSTIs was associated with an increased DM risk, which partially attenuated when adjusted for BMI changes and other variables.","journal":"Clinical Infectious Diseases","year":2024,"id":421991,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8789,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364613,"name":"Loveleen Bansi‐Matharu","orcid":"0000-0002-0233-7622","position":1,"is_corresponding":false},{"id":11862,"name":"Matthew Law","orcid":"0000-0002-3540-8837","position":2,"is_corresponding":false},{"id":364617,"name":"Robert Zangerle","orcid":"0000-0002-5375-7299","position":3,"is_corresponding":false},{"id":459826,"name":"Andri Rauch","orcid":"0000-0001-5297-6062","position":4,"is_corresponding":false},{"id":459829,"name":"Philip Tarr","orcid":"0000-0002-1488-5407","position":5,"is_corresponding":false},{"id":364590,"name":"Lauren Greenberg","orcid":"0000-0003-1554-0408","position":6,"is_corresponding":false},{"id":364592,"name":"Bastian Neesgaard","orcid":"0000-0003-0215-0144","position":7,"is_corresponding":false},{"id":883658,"name":"Nadine Jaschinski","orcid":"0000-0003-4847-2966","position":8,"is_corresponding":false},{"id":1214991,"name":"Stéphane De Wit","orcid":"0000-0002-8079-6170","position":9,"is_corresponding":false},{"id":241754,"name":"Ferdinand W.N.M. Wit","orcid":"0000-0003-2066-8115","position":10,"is_corresponding":false},{"id":364601,"name":"Antonella d’Arminio Monforte","orcid":"0000-0003-0073-1789","position":11,"is_corresponding":false},{"id":364620,"name":"Éric Fontas","orcid":"0000-0002-1849-9626","position":12,"is_corresponding":false},{"id":364602,"name":"Antonella Castagna","orcid":"0000-0002-8338-9714","position":13,"is_corresponding":false},{"id":1018179,"name":"Melanie Stecher","orcid":"0000-0002-3460-1299","position":14,"is_corresponding":false},{"id":1077830,"name":"Éric Florence","orcid":"0000-0002-7004-9120","position":15,"is_corresponding":false},{"id":1214992,"name":"Josip Begovać","orcid":"0000-0003-2641-4327","position":16,"is_corresponding":false},{"id":200816,"name":"Cristina Mussini","orcid":null,"position":17,"is_corresponding":false},{"id":104889,"name":"Anders Sönnerborg","orcid":"0000-0001-8928-3374","position":18,"is_corresponding":false},{"id":1215519,"name":"Akaki Abutidze","orcid":null,"position":19,"is_corresponding":false},{"id":1215520,"name":"Ana Groh","orcid":null,"position":20,"is_corresponding":false},{"id":364607,"name":"Vani Vannappagari","orcid":"0000-0002-0157-9689","position":21,"is_corresponding":false},{"id":635335,"name":"Cal Cohen","orcid":null,"position":22,"is_corresponding":false},{"id":1061033,"name":"Lital Young","orcid":null,"position":23,"is_corresponding":false},{"id":1207797,"name":"Sean R Hosein","orcid":null,"position":24,"is_corresponding":false},{"id":364591,"name":"Lene Ryom","orcid":"0000-0002-6436-6461","position":25,"is_corresponding":false},{"id":364615,"name":"Kathy Petoumenos","orcid":"0000-0001-7534-7154","position":26,"is_corresponding":false},{"id":960465,"name":"Dhanushi Rupasinghe","orcid":"0000-0002-4014-3570","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:57:41.370244Z","pmid":"39117341","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}