{"doi":"10.1093/cid/ciae384","title":"Effects of Semaglutide on Muscle Structure and Function in the SLIM LIVER Study","abstract":"BACKGROUND: Semaglutide is highly effective for decreasing weight. Concomitant loss of muscle mass often accompanies weight loss and may have consequences on muscle function. METHODS: This is a secondary analysis from the SLIM LIVER (Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, ACTG A5371) study, a single-arm study of semaglutide in people with human immunodeficiency virus (HIV, PWH) with metabolic dysfunction-associated steatotic liver diseases (MASLD). Participants received subcutaneous semaglutide for 24 weeks (titrated to 1 mg/week by week 4). Psoas volume and fat fraction were assessed from liver magnetic resonance imaging, and physical function was assessed by 10-time chair rise test and 4 m gait speed. Mean change from baseline to week 24 was estimated with linear regression modeling. RESULTS: Fifty-one PWH were enrolled (muscle measures n = 46). The mean age was 50 years (standard deviation, 11), body mass index was 35.5 kg/m2 (5.6), 43% were women, 33% Black, and 39% Hispanic/Latino. Psoas muscle volume decreased by 9.3% (95% confidence interval [CI]: -13.4 to -5.2; P < .001) over 24 weeks, but psoas muscle fat did not significantly change (-0.42%; 95% CI: -1.00 to .17; P = .16). Chair rise and gait speed showed nonsignificant improvements of 1.27 seconds (95% CI: -2.7 to .10) and 0.05 m/sec (95% CI: -.01 to .10), respectively (both P > .07). The prevalence of slow gait speed (<1 m/sec) decreased from 63% to 46% (P = .029). CONCLUSIONS: In PWH receiving semaglutide for MASLD, despite decreased psoas muscle volume, there was no significant change in physical function, suggesting function was maintained despite significant loss of muscle. CLINICAL TRIALS REGISTRATION: NCT04216589.","journal":"Clinical Infectious Diseases","year":2024,"id":420287,"datarank":0.9920861424809753,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.4545583017125588,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.4545583017125588,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":33,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8008,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04216589"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240258,"name":"Jordan E. Lake","orcid":"0000-0002-0640-5514","position":1,"is_corresponding":false},{"id":582992,"name":"Douglas Kitch","orcid":null,"position":2,"is_corresponding":false},{"id":504019,"name":"Amy Kantor","orcid":null,"position":3,"is_corresponding":false},{"id":845667,"name":"Raja Muthupillai","orcid":"0000-0001-5041-2562","position":4,"is_corresponding":false},{"id":419481,"name":"Carlee Moser","orcid":"0000-0001-5601-9112","position":5,"is_corresponding":false},{"id":411814,"name":"Pablo F. Belaunzarán-Zamudio","orcid":"0000-0003-4775-4734","position":6,"is_corresponding":false},{"id":109430,"name":"Todd T. Brown","orcid":"0000-0001-8599-278X","position":7,"is_corresponding":false},{"id":254443,"name":"Kathleen E. Corey","orcid":"0000-0003-2882-7264","position":8,"is_corresponding":false},{"id":328573,"name":"Alan Landay","orcid":"0000-0001-9645-1356","position":9,"is_corresponding":false},{"id":424033,"name":"Anchalee Avihingsanon","orcid":"0000-0003-3222-9611","position":10,"is_corresponding":false},{"id":383614,"name":"Fred R. Sattler","orcid":"0000-0002-1986-6803","position":11,"is_corresponding":false},{"id":242505,"name":"Kristine M. Erlandson","orcid":"0000-0003-0808-6729","position":12,"is_corresponding":false},{"id":796427,"name":"Grace L. Ditzenberger","orcid":"0000-0002-2318-3239","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:57:25.777459Z","pmid":"39046173","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}