{"doi":"10.1093/cid/ciae133","title":"Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care","abstract":"BACKGROUND: We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care. METHODS: Fifty-five hospitals in 30 US states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients <21 years admitted 12 March 2020-30 December 2021 to the pediatric intensive care unit (PICU) or high-acuity unit for acute COVID-19 were included. RESULTS: Of 1274 patients, 105 (8.2%) had an ICC, including 33 (31.4%) hematologic malignancies, 24 (22.9%) primary immunodeficiencies and disorders of hematopoietic cells, 19 (18.1%) nonmalignant organ failure with solid-organ transplantation, 16 (15.2%) solid tumors, and 13 (12.4%) autoimmune disorders. Patients with ICCs were older, had more underlying renal conditions, and had lower white blood cell and platelet counts than those without ICCs, but had similar clinical disease severity upon admission. In-hospital mortality from COVID-19 was higher (11.4% vs 4.6%, P = .005) and hospitalization was longer (P = .01) in patients with ICCs. New major morbidities upon discharge were not different between those with and without ICC (10.5% vs 13.9%, P = .40). In patients with ICCs, bacterial coinfection was more common in those with life-threatening COVID-19. CONCLUSIONS: In this national case series of patients <21 years of age with acute COVID-19 admitted for intensive care, existence of a prior ICCs were associated with worse clinical outcomes. Reassuringly, most patients with ICCs hospitalized in the PICU for severe acute COVID-19 survived and were discharged home without new severe morbidities.","journal":"Clinical Infectious Diseases","year":2024,"id":495120,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5976,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":11544,"name":"Brenna LaBere","orcid":"0000-0002-7967-7270","position":1,"is_corresponding":false},{"id":690466,"name":"Cameron C. Young","orcid":"0000-0001-7323-4834","position":2,"is_corresponding":false},{"id":725851,"name":"Laura D. Zambrano","orcid":"0000-0002-0145-9142","position":3,"is_corresponding":false},{"id":451849,"name":"Margaret M. Newhams","orcid":"0000-0002-3738-1172","position":4,"is_corresponding":false},{"id":843146,"name":"Suden Kücükak","orcid":null,"position":5,"is_corresponding":false},{"id":1029048,"name":"Elizabeth R McNamara","orcid":null,"position":6,"is_corresponding":false},{"id":690474,"name":"Elizabeth H. Mack","orcid":"0000-0002-6913-6892","position":7,"is_corresponding":false},{"id":260218,"name":"Julie C. Fitzgerald","orcid":"0000-0002-7627-1689","position":8,"is_corresponding":false},{"id":242091,"name":"Katherine Irby","orcid":"0000-0001-8111-3215","position":9,"is_corresponding":false},{"id":351595,"name":"Aline B. Maddux","orcid":"0000-0002-0949-4284","position":10,"is_corresponding":false},{"id":236972,"name":"Jennifer E. Schuster","orcid":"0000-0001-6365-566X","position":11,"is_corresponding":false},{"id":242090,"name":"Michele Kong","orcid":"0000-0001-6596-3965","position":12,"is_corresponding":false},{"id":690476,"name":"Heda Dapul","orcid":"0000-0002-7209-1285","position":13,"is_corresponding":false},{"id":590481,"name":"Stephanie P. Schwartz","orcid":"0000-0003-4314-6117","position":14,"is_corresponding":false},{"id":250755,"name":"Melania M. Bembea","orcid":"0000-0003-4984-520X","position":15,"is_corresponding":false},{"id":242109,"name":"Laura L. Loftis","orcid":"0000-0002-2446-3320","position":16,"is_corresponding":false},{"id":1106108,"name":"Amanda Kolmar","orcid":"0000-0002-4703-2937","position":17,"is_corresponding":false},{"id":690470,"name":"Christopher Babbitt","orcid":"0000-0001-6744-1052","position":18,"is_corresponding":false},{"id":451855,"name":"Ryan A. Nofziger","orcid":"0000-0001-7057-2686","position":19,"is_corresponding":false},{"id":446153,"name":"Mark W. Hall","orcid":"0000-0002-9595-2308","position":20,"is_corresponding":false},{"id":451854,"name":"Shira J. Gertz","orcid":"0000-0001-8119-6006","position":21,"is_corresponding":false},{"id":242093,"name":"Natalie Z. Cvijanovich","orcid":"0000-0001-9905-4137","position":22,"is_corresponding":false},{"id":746065,"name":"Matt S. Zinter","orcid":"0000-0003-3351-3278","position":23,"is_corresponding":false},{"id":105913,"name":"Natasha Halasa","orcid":"0000-0002-6381-1826","position":24,"is_corresponding":false},{"id":690472,"name":"Tamara T. Bradford","orcid":"0000-0001-5220-7423","position":25,"is_corresponding":false},{"id":243973,"name":"Gwenn E. McLaughlin","orcid":null,"position":26,"is_corresponding":false},{"id":690468,"name":"Aalok R. Singh","orcid":"0000-0002-7186-1882","position":27,"is_corresponding":false},{"id":376641,"name":"Charlotte V. Hobbs","orcid":"0000-0003-4829-0791","position":28,"is_corresponding":false},{"id":778563,"name":"Kari Wellnitz","orcid":"0000-0001-9451-8879","position":29,"is_corresponding":false},{"id":236964,"name":"Mary Allen Staat","orcid":"0000-0003-1788-8037","position":30,"is_corresponding":false},{"id":242098,"name":"Bria M. Coates","orcid":"0000-0003-4264-5440","position":31,"is_corresponding":false},{"id":1341890,"name":"Hillary R Crandall","orcid":null,"position":32,"is_corresponding":false},{"id":690477,"name":"Mia Maamari","orcid":"0000-0002-0118-1638","position":33,"is_corresponding":false},{"id":690478,"name":"Kevin Havlin","orcid":"0000-0002-4917-2482","position":34,"is_corresponding":false},{"id":242095,"name":"Adam J. Schwarz","orcid":"0000-0003-0651-8487","position":35,"is_corresponding":false},{"id":690473,"name":"Christopher L. Carroll","orcid":"0000-0002-2054-6938","position":36,"is_corresponding":false},{"id":664688,"name":"Emily R. Levy","orcid":"0000-0001-8447-7663","position":37,"is_corresponding":false},{"id":781622,"name":"Kristin Moffitt","orcid":"0000-0003-4581-7199","position":38,"is_corresponding":false},{"id":236962,"name":"Angela P. Campbell","orcid":"0000-0002-2576-482X","position":39,"is_corresponding":false},{"id":242084,"name":"Adrienne G. Randolph","orcid":"0000-0002-3084-3071","position":40,"is_corresponding":false},{"id":11547,"name":"Janet Chou","orcid":"0000-0002-4610-2657","position":41,"is_corresponding":false},{"id":779010,"name":"Overcoming COVID-19 Investigators","orcid":null,"position":42,"is_corresponding":false},{"id":451850,"name":"Mary Glas Gaspers","orcid":"0000-0003-0561-9411","position":44,"is_corresponding":false},{"id":242092,"name":"Katri Typpo","orcid":"0000-0001-9095-3101","position":45,"is_corresponding":false},{"id":243970,"name":"Ronald C. Sanders","orcid":null,"position":46,"is_corresponding":false},{"id":631689,"name":"Adam J Schwarz","orcid":null,"position":48,"is_corresponding":false},{"id":91739,"name":"Pia S. Pannaraj","orcid":"0000-0002-5208-0933","position":50,"is_corresponding":false},{"id":1028460,"name":"Helen Harvey","orcid":"0000-0001-5835-9575","position":51,"is_corresponding":false},{"id":682602,"name":"Emily Port","orcid":null,"position":55,"is_corresponding":false},{"id":1341891,"name":"Sara Shankman","orcid":null,"position":56,"is_corresponding":false},{"id":1029052,"name":"Rachel Mansour","orcid":null,"position":57,"is_corresponding":false},{"id":690469,"name":"John S. Giuliano","orcid":"0000-0003-2753-8460","position":59,"is_corresponding":false},{"id":1003339,"name":"Paula S. Espinal","orcid":null,"position":61,"is_corresponding":false},{"id":242097,"name":"Keiko M. Tarquinio","orcid":"0000-0003-2688-1021","position":62,"is_corresponding":false},{"id":91749,"name":"Kelly N. Michelson","orcid":"0000-0002-9714-9535","position":63,"is_corresponding":false},{"id":1341568,"name":"Guru Bhoojhawon","orcid":"0000-0003-1165-6905","position":67,"is_corresponding":false},{"id":1341892,"name":"Janice E Sullivan","orcid":null,"position":68,"is_corresponding":false},{"id":451851,"name":"Vicki Montgomery","orcid":"0009-0002-7329-4866","position":69,"is_corresponding":false},{"id":1341893,"name":"Tamara T Bradford","orcid":null,"position":71,"is_corresponding":false},{"id":1106110,"name":"Ana Lía Graciano","orcid":"0000-0001-5327-9701","position":73,"is_corresponding":false},{"id":1341894,"name":"Margaret M Newhams","orcid":null,"position":75,"is_corresponding":false},{"id":859323,"name":"Sabrina Chen","orcid":"0009-0009-2805-9059","position":76,"is_corresponding":false},{"id":1341895,"name":"Cameron C Young","orcid":null,"position":77,"is_corresponding":false},{"id":230147,"name":"Mary Beth F. Son","orcid":"0000-0002-7394-2862","position":79,"is_corresponding":false},{"id":376213,"name":"Ryan W. Carroll","orcid":"0000-0002-7513-7023","position":82,"is_corresponding":false},{"id":1341569,"name":"Phoebe H. Yager","orcid":"0000-0002-6957-1624","position":83,"is_corresponding":false},{"id":1341570,"name":"Neil D. Fernandes","orcid":"0000-0002-3024-1994","position":84,"is_corresponding":false},{"id":242094,"name":"Heidi R. Flori","orcid":"0000-0002-6047-6970","position":85,"is_corresponding":false},{"id":451852,"name":"Janet R. Hume","orcid":"0000-0002-8891-6800","position":86,"is_corresponding":false},{"id":1042273,"name":"Brandi A. Johnson","orcid":null,"position":88,"is_corresponding":false},{"id":843005,"name":"Noelle M. Drapeau","orcid":null,"position":89,"is_corresponding":false},{"id":570087,"name":"Supriya Behl","orcid":"0000-0002-6672-4824","position":90,"is_corresponding":false},{"id":30674,"name":"Lacy Malloch","orcid":"0000-0001-9523-1706","position":92,"is_corresponding":false},{"id":842156,"name":"Lora Martin","orcid":"0009-0000-7750-8468","position":93,"is_corresponding":false},{"id":57786,"name":"Sarah McGraw","orcid":"0000-0002-3208-8129","position":94,"is_corresponding":false},{"id":1341896,"name":"Jennifer E Schuster","orcid":null,"position":95,"is_corresponding":false},{"id":351593,"name":"Philip C. Spinella","orcid":"0000-0003-1721-0541","position":96,"is_corresponding":false},{"id":451853,"name":"Melissa L. Cullimore","orcid":"0000-0002-9150-9923","position":98,"is_corresponding":false},{"id":420535,"name":"Russell J. McCulloh","orcid":"0000-0002-0403-6639","position":99,"is_corresponding":false},{"id":333680,"name":"Courtney M. Rowan","orcid":"0000-0003-1393-6476","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:09:15.528853Z","pmid":"38465976","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}