{"doi":"10.1093/cid/ciae081","title":"Durability of Protection Against COVID-19 Through the Delta Surge for the NVX-CoV2373 Vaccine","abstract":"BACKGROUND: Protein-based vaccines for coronavirus disease 2019 (COVID-19) provide a traditional vaccine platform with long-lasting protection for non-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogens and may complement messenger RNA vaccines as a booster dose. While NVX-CoV2373 showed substantial early efficacy, the durability of protection has not been delineated. METHODS: The PREVENT-19 vaccine trial used a blinded crossover design; the original placebo arm received NVX-CoV2373 after efficacy was established. Using novel statistical methods that integrate surveillance data of circulating strains with post-crossover cases, we estimated placebo-controlled vaccine efficacy and durability of NVX-CoV2373 against both pre-Delta and Delta strains of SARS-CoV-2. RESULTS: Vaccine efficacy against pre-Delta strains of COVID-19 was 89% (95% CI, 75-95%) and 87% (72-94%) at 0 and 90 days after 2 doses of NVX-CoV2373, respectively, with no evidence of waning (P = .93). Vaccine efficacy against the Delta strain was 88% (71-95%), 82% (56-92%), and 77% (44-90%) at 40, 120, and 180 days, respectively, with evidence of waning (P < .01). In sensitivity analyses, the estimated Delta vaccine efficacy at 120 days ranged from 66% (15-86%) to 89% (74-95%) per various assumptions of the surveillance data. CONCLUSIONS: NVX-CoV2373 has high initial efficacy against pre-Delta and Delta strains of COVID-19 with little evidence of waning for pre-Delta strains through 90 days and moderate waning against Delta strains over 180 days.","journal":"Clinical Infectious Diseases","year":2024,"id":437855,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344858,"name":"Allyson Mateja","orcid":"0000-0002-2810-478X","position":1,"is_corresponding":false},{"id":399107,"name":"Michael P. Fay","orcid":"0000-0002-8643-9625","position":2,"is_corresponding":false},{"id":708779,"name":"Craig A. Magaret","orcid":"0000-0002-5056-2664","position":3,"is_corresponding":false},{"id":331739,"name":"Yunda Huang","orcid":"0000-0003-1546-6172","position":4,"is_corresponding":false},{"id":379156,"name":"Youyi Fong","orcid":"0000-0002-4230-6863","position":5,"is_corresponding":false},{"id":368507,"name":"Heather Angier","orcid":"0000-0002-6313-1927","position":6,"is_corresponding":false},{"id":105609,"name":"Martha Nason","orcid":"0000-0002-0110-881X","position":7,"is_corresponding":false},{"id":249715,"name":"Cynthia L. Gay","orcid":"0000-0002-3620-3059","position":8,"is_corresponding":false},{"id":242121,"name":"Karen L. Kotloff","orcid":"0000-0003-1808-6431","position":9,"is_corresponding":false},{"id":375860,"name":"Wayne Woo","orcid":"0000-0002-4272-4264","position":10,"is_corresponding":false},{"id":253722,"name":"Iksung Cho","orcid":"0000-0001-5927-5410","position":11,"is_corresponding":false},{"id":804379,"name":"Lisa M. Dunkle","orcid":"0000-0003-2973-0245","position":12,"is_corresponding":false},{"id":390353,"name":"Dean Follmann","orcid":"0000-0003-4073-0393","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:00:34.490087Z","pmid":"38372392","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}