{"doi":"10.1093/cid/ciad704","title":"Vaccine Effectiveness Against Pediatric Influenza-A–Associated Urgent Care, Emergency Department, and Hospital Encounters During the 2022–2023 Season: VISION Network","abstract":"BACKGROUND: During the 2022-2023 influenza season, the United States experienced the highest influenza-associated pediatric hospitalization rate since 2010-2011. Influenza A/H3N2 infections were predominant. METHODS: We analyzed acute respiratory illness (ARI)-associated emergency department or urgent care (ED/UC) encounters or hospitalizations at 3 health systems among children and adolescents aged 6 months-17 years who had influenza molecular testing during October 2022-March 2023. We estimated influenza A vaccine effectiveness (VE) using a test-negative approach. The odds of vaccination among influenza-A-positive cases and influenza-negative controls were compared after adjusting for confounders and applying inverse-propensity-to-be-vaccinated weights. We developed overall and age-stratified VE models. RESULTS: Overall, 13 547 of 44 787 (30.2%) eligible ED/UC encounters and 263 of 1862 (14.1%) hospitalizations were influenza-A-positive cases. Among ED/UC patients, 15.2% of influenza-positive versus 27.1% of influenza-negative patients were vaccinated; VE was 48% (95% confidence interval [CI], 44-52%) overall, 53% (95% CI, 47-58%) among children aged 6 months-4 years, and 38% (95% CI, 30-45%) among those aged 9-17 years. Among hospitalizations, 17.5% of influenza-positive versus 33.4% of influenza-negative patients were vaccinated; VE was 40% (95% CI, 6-61%) overall, 56% (95% CI, 23-75%) among children ages 6 months-4 years, and 46% (95% CI, 2-70%) among those 5-17 years. CONCLUSIONS: During the 2022-2023 influenza season, vaccination reduced the risk of influenza-associated ED/UC encounters and hospitalizations by almost half (overall VE, 40-48%). Influenza vaccination is a critical tool to prevent moderate-to-severe influenza illness in children and adolescents.","journal":"Clinical Infectious Diseases","year":2023,"id":327829,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9265,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":852590,"name":"Zachary A. Weber","orcid":"0000-0001-6896-5050","position":1,"is_corresponding":false},{"id":758980,"name":"Duck‐Hye Yang","orcid":null,"position":2,"is_corresponding":false},{"id":360572,"name":"Nicola P. Klein","orcid":"0000-0003-1777-4814","position":3,"is_corresponding":false},{"id":371262,"name":"Malini B. DeSilva","orcid":"0000-0003-3705-1672","position":4,"is_corresponding":false},{"id":852584,"name":"Kristin Dascomb","orcid":"0000-0002-7422-060X","position":5,"is_corresponding":false},{"id":371265,"name":"Stephanie A. Irving","orcid":"0000-0001-7437-6797","position":6,"is_corresponding":false},{"id":360571,"name":"Allison L. 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Ball","orcid":"0000-0002-0903-8107","position":24,"is_corresponding":false},{"id":852588,"name":"Margaret M. Dunne","orcid":"0000-0002-0664-8954","position":25,"is_corresponding":false},{"id":1049221,"name":"Lindsey Kirshner","orcid":null,"position":26,"is_corresponding":false},{"id":249372,"name":"Jessie R. Chung","orcid":"0000-0001-5205-966X","position":27,"is_corresponding":false},{"id":105978,"name":"Mark W. 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