{"doi":"10.1093/cid/ciad654","title":"Long-term Hepatitis B and Liver Outcomes Among Adults Taking Tenofovir-Containing Antiretroviral Therapy for HBV/HIV Coinfection in Zambia","abstract":"BACKGROUND: Long-term outcomes of tenofovir-containing antiretroviral therapy (ART) for hepatitis B virus (HBV)/human immunodeficiency virus (HIV) coinfection were evaluated in Zambia. METHODS: A prospective cohort of adults with HIV and hepatitis B surface antigen (HBsAg)-positivity was enrolled at ART initiation. On tenofovir-containing ART, we ascertained HBV viral load (VL) non-suppression, alanine aminotransferase (ALT) elevation, serologic end-points, progression of liver fibrosis based on elastography, and hepatocellular carcinoma (HCC) incidence. We also described a subgroup (low HBV VL and no/minimal fibrosis at baseline) that, under current international guidelines, would not have been treated in the absence of their HIV infection. RESULTS: Among 289 participants at ART start, median age was 34 years, 40.1% were women, median CD4 count was 191 cells/mm3, 44.2% were hepatitis B e antigen-positive, and 28.4% had liver fibrosis/cirrhosis. Over median 5.91 years of ART, 13.6% developed HBV viral non-suppression, which was associated with advanced HIV disease. ALT elevation on ART was linked with HBV VL non-suppression. Regression of fibrosis and cirrhosis were common, progression to cirrhosis was absent, and no cases of HCC were ascertained. HBsAg seroclearance was 9.4% at 2 and 15.4% at 5 years, with higher rates among patients with low baseline HBV replication markers. CONCLUSIONS: Reassuring long-term liver outcomes were ascertained during tenofovir-based ART for HBV/HIV coinfection in Zambia. Higher than expected HBsAg seroclearance during ART underscores the need to include people with HIV in HBV cure research.","journal":"Clinical Infectious Diseases","year":2023,"id":343626,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8668,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1081628,"name":"Kalongo Hamusonde","orcid":"0000-0003-1927-8101","position":1,"is_corresponding":false},{"id":764937,"name":"Guy Muula","orcid":null,"position":2,"is_corresponding":false},{"id":475187,"name":"Mah Asombang","orcid":"0000-0002-7455-4255","position":3,"is_corresponding":false},{"id":764283,"name":"Carlotta Riebensahm","orcid":"0000-0002-7394-6230","position":4,"is_corresponding":false},{"id":764936,"name":"Helen Chitundu","orcid":null,"position":5,"is_corresponding":false},{"id":1082108,"name":"Veronica Sunkuntu-Sichizya","orcid":null,"position":6,"is_corresponding":false},{"id":442329,"name":"Debika Bhattacharya","orcid":"0000-0002-2136-7763","position":7,"is_corresponding":false},{"id":329540,"name":"Edford Sinkala","orcid":"0000-0002-5756-5569","position":8,"is_corresponding":false},{"id":331565,"name":"Georg M. Lauer","orcid":"0000-0002-9792-4271","position":9,"is_corresponding":false},{"id":270866,"name":"Raymond T. Chung","orcid":"0000-0001-7587-718X","position":10,"is_corresponding":false},{"id":1082109,"name":"Wilson Mbewe","orcid":null,"position":11,"is_corresponding":false},{"id":4469,"name":"Matthias Egger","orcid":"0000-0001-7462-5132","position":12,"is_corresponding":false},{"id":413973,"name":"Samuel Bosomprah","orcid":"0000-0002-2826-3887","position":13,"is_corresponding":false},{"id":364593,"name":"Gilles Wandeler","orcid":"0000-0002-5278-8763","position":14,"is_corresponding":false},{"id":393581,"name":"Michael J. Vinikoor","orcid":"0000-0002-3862-7795","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:11:26.556051Z","pmid":"37997691","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}