{"doi":"10.1093/cid/ciad336","title":"Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model","abstract":"For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.","journal":"Clinical Infectious Diseases","year":2023,"id":362660,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":978172,"name":"John Law","orcid":"0000-0002-4915-919X","position":1,"is_corresponding":false},{"id":1116187,"name":"Thomas Pietschmann","orcid":"0000-0001-5138-6239","position":2,"is_corresponding":false},{"id":292100,"name":"Stuart C. Ray","orcid":"0000-0002-1051-7260","position":3,"is_corresponding":false},{"id":459545,"name":"Jens Bukh","orcid":"0000-0002-7815-4806","position":4,"is_corresponding":false},{"id":428264,"name":"Rowena A. Bull","orcid":"0000-0002-9844-3744","position":5,"is_corresponding":false},{"id":270866,"name":"Raymond T. Chung","orcid":"0000-0001-7587-718X","position":6,"is_corresponding":false},{"id":227825,"name":"D. Lorne Tyrrell","orcid":"0000-0002-0983-7267","position":7,"is_corresponding":false},{"id":59199,"name":"Michael Houghton","orcid":"0000-0003-3762-6771","position":8,"is_corresponding":false},{"id":104737,"name":"Charles M. Rice","orcid":"0000-0003-3087-8079","position":9,"is_corresponding":false},{"id":242482,"name":"T. Jake Liang","orcid":"0000-0003-3828-702X","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:14:23.749325Z","pmid":"37579208","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}