{"doi":"10.1093/cid/ciad289","title":"Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort","abstract":"BACKGROUND: Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack of prospective community-based cohort studies with intensive monitoring. METHODS: To address this gap, we enacted the PREVAIL cohort, a Centers for Disease Control and Prevention-sponsored birth cohort in Cincinnati, Ohio, where children were followed from 0 to 2 years of age. Weekly text surveys were administered to record acute respiratory illnesses (ARIs), which were defined as the presence of cough or fever (≥38°C). Weekly midturbinate nasal swabs were collected and tested using the Luminex Respiratory Pathogen Panel, which detected 16 viral pathogens. Viral infection was defined as ≥1 positive tests from the same virus or viral subtype ≤30 days of a previous positive test. Maternal report and medical chart abstractions identified healthcare utilization. RESULTS: From 4/2017 to 7/2020, 245 mother-infant pairs were recruited and followed. From the 13 781 nasal swabs tested, a total of 2211 viral infections were detected, of which 821 (37%) were symptomatic. Children experienced 9.4 respiratory viral infections/child-year; half were rhinovirus/enterovirus. Viral ARI incidence was 3.3 episodes/child-year. Emergency department visits or hospitalization occurred with only 15% of respiratory syncytial virus infections, 10% of influenza infections, and only 4% of all viral infections. Regardless of pathogen, most infections were asymptomatic or mild. CONCLUSIONS: Respiratory viral infections are common in children 0-2 years. Most viral infections are asymptomatic or non-medically attended, underscoring the importance of community-based cohort studies.","journal":"Clinical Infectious Diseases","year":2023,"id":320579,"datarank":1.25836421540376,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.6745911706871658,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.6745911706871658,"corpus_percentile":83.65436682911735,"corpus_rank":2114,"citation_count":48,"citer_count":43,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5064,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":979155,"name":"Shannon C Conrey","orcid":"0000-0003-3715-5842","position":1,"is_corresponding":false},{"id":236966,"name":"Monica McNeal","orcid":"0000-0002-3784-9062","position":2,"is_corresponding":false},{"id":979156,"name":"Allison R Burrell","orcid":"0000-0002-2271-8430","position":3,"is_corresponding":false},{"id":310341,"name":"Rachel M. Burke","orcid":"0000-0002-5678-5826","position":4,"is_corresponding":false},{"id":310342,"name":"Claire P. Mattison","orcid":"0000-0001-8558-8779","position":5,"is_corresponding":false},{"id":619231,"name":"Meredith McMorrow","orcid":"0000-0001-6363-4033","position":6,"is_corresponding":false},{"id":236977,"name":"Daniel C. Payne","orcid":"0000-0002-5871-911X","position":7,"is_corresponding":false},{"id":550150,"name":"Ardythe L. Morrow","orcid":"0000-0002-1126-4525","position":8,"is_corresponding":false},{"id":236964,"name":"Mary Allen Staat","orcid":"0000-0003-1788-8037","position":9,"is_corresponding":false},{"id":964073,"name":"Zheyi Teoh","orcid":"0000-0003-2211-0764","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:07:22.377587Z","pmid":"37157868","pmcid":"PMC10838707","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}