{"doi":"10.1093/cid/ciad188","title":"Reply to Upton et al","abstract":"To theEditor—We thank Upton et al [1] for taking an interest in our article and for raising excellent points about the interpretation of our cerebrospinal fluid (CSF) pharmacokinetic results [2]. We agree that our results provide no definitive answers on the role of newly implemented drugs such as bedaquiline and delamanid for the treatment of tuberculosis meningitis (TBM), including drug-resistant disease, and we wholeheartedly encourage others to continue explore their use further through clinical practice and research endeavors. The point about the “stickiness” of bedaquiline is valid and important to consider. For additional detail on our CSF collection procedure, we used a prepared lumbar puncture kit; CSF was collected through a 3.5-inch spinal needle and a 3-way stopcock directly into polypropylene specimen vials, pipetted into polypropylene cryovials, and frozen at −80°C until shipment and analysis. While the lack of plastic tubing decreased potential drug loss, it is possible that some of the bedaquiline adsorbed to the polypropylene vials, as has been described previously in a pilot experiment [3]. We applaud the work by Upton and colleagues [4] to test and fine tune collection strategies to more accurately measure CSF bedaquiline concentrations. This provides an invaluable technique for future bedaquiline CSF pharmacokinetic research and will allow for better comparison of results between studies and patients.","journal":"Clinical Infectious Diseases","year":2023,"id":404062,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338061,"name":"Maia Kipiani","orcid":null,"position":1,"is_corresponding":false},{"id":267037,"name":"Charles A. Peloquin","orcid":"0000-0001-9002-7052","position":2,"is_corresponding":false},{"id":332451,"name":"Russell R. Kempker","orcid":"0000-0002-7188-4996","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-19T01:20:40.264741Z","pmid":"36978221","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}