{"doi":"10.1093/cid/ciad034","title":"Perspectives on Adherence From the ACTG 5360 MINMON Trial: A Minimum Monitoring Approach With 12 Weeks of Sofosbuvir/Velpatasvir in Chronic Hepatitis C Treatment","abstract":"BACKGROUND: With the advent of efficacious oral direct-acting antivirals (DAAs) for hepatitis C virus (HCV), identification of characteristics associated with adherence is critical to treatment success. We examined correlates of sub-optimal adherence to HCV therapy in a single-arm, multinational, clinical trial. METHODS: ACTG A5360 enrolled HCV treatment-naive persons without decompensated cirrhosis from 5 countries. All participants received a 12-weeks course of sofosbuvir/velpatasvir at entry. In-person visits occurred at initiation and week 24, sustained virologic response (SVR) assessment. Adherence at week 4 was collected remotely and was dichotomized optimal (100%, no missed doses) versus sub-optimal (<100%). Correlates of sub-optimal adherence were explored using logistic regression. RESULTS: In total, 400 participants enrolled; 399 initiated treatment; 395/397 (99%) reported completing at week 24. Median age was 47 years with 35% female. Among the 368 reporting optimal adherence at week 4 SVR was 96.5% (95% confidence interval [CI] [94.1%, 97.9%]) vs 77.8% (95% CI [59.2%, 89.4%]) P value < .001. In the multivariate model age <30 years and being a US participant were independently associated with early sub-optimal adherence. Participants <30 years were 7.1 times more likely to have early sub-optimal adherence compared to their older counterparts. CONCLUSIONS: Self-reported optimal adherence at week 4 was associated with SVR. Early self-reported adherence could be used to identify those at higher risk of treatment failure and may benefit from additional support. Younger individuals <30 years may also be prioritized for additional adherence support. Clinical Trials Registration. NCT03512210.","journal":"Clinical Infectious Diseases","year":2023,"id":343863,"datarank":0.5376979163723141,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.1418393169300252,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.1418393169300252,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9295,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03512210"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":434569,"name":"Laura Smeaton","orcid":"0000-0001-7243-4703","position":1,"is_corresponding":false},{"id":969805,"name":"Irena Brates","orcid":null,"position":2,"is_corresponding":false},{"id":442329,"name":"Debika Bhattacharya","orcid":"0000-0002-2136-7763","position":3,"is_corresponding":false},{"id":312536,"name":"Benjamin P. Linas","orcid":"0000-0002-9781-9690","position":4,"is_corresponding":false},{"id":1082306,"name":"Bruce Kreter","orcid":null,"position":5,"is_corresponding":false},{"id":1082307,"name":"Sandra Wagner-Cardoso","orcid":null,"position":6,"is_corresponding":false},{"id":432914,"name":"Sunil S. Solomon","orcid":"0000-0002-3296-1514","position":7,"is_corresponding":false},{"id":315359,"name":"Mark Sulkowski","orcid":"0000-0002-2145-6352","position":8,"is_corresponding":false},{"id":311026,"name":"Gregory K. Robbins","orcid":"0000-0001-7545-5817","position":9,"is_corresponding":false},{"id":1039309,"name":"Leonard Sowah","orcid":"0000-0002-4389-1013","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:11:26.556051Z","pmid":"36694361","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}