{"doi":"10.1093/cid/ciac985","title":"Prevalence of<i>Salmonella</i>in Stool During the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015–2018","abstract":"BACKGROUND: Non-typhoidal Salmonella (NTS) is a common cause of gastroenteritis in young children, with limited data on NTS serovars and antimicrobial resistance in Africa. METHODS: We determined the prevalence of Salmonella spp. and frequency of antimicrobial resistance among serovars identified in stools of 0-59 month-old children with moderate-to-severe diarrhea (MSD) and controls enrolled in the Vaccine Impact on Diarrhea in Africa (VIDA) Study in The Gambia, Mali, and Kenya in 2015-2018, and compared with data from the Global Enteric Multicenter Study (GEMS; 2007-2010) and the GEMS-1A study (2011). Salmonella spp. was detected by quantitative real-time PCR (qPCR) and culture-based methods. Identification of serovars was determined by microbiological methods. RESULTS: By qPCR, the prevalence of Salmonella spp. among MSD cases was 4.0%, 1.6%, and 1.9% and among controls was 4.6%, 2.4%, and 1.6% in The Gambia, Mali, and Kenya, respectively, during VIDA. We observed year-to-year variation in serovar distribution and variation between sites. In Kenya, Salmonella enterica serovar Typhimurium decreased (78.1% to 23.1%; P < .001) among cases and controls from 2007 to 2018, whereas serogroup O:8 increased (8.7% to 38.5%; P = .04). In The Gambia, serogroup O:7 decreased from 2007 to 2018 (36.3% to 0%; P = .001) but S. enterica serovar Enteritidis increased during VIDA (2015 to 2018; 5.9% to 50%; P = .002). Only 4 Salmonella spp. were isolated in Mali during all 3 studies. Multidrug resistance was 33.9% in Kenya and 0.8% in The Gambia across all 3 studies. Ceftriaxone resistance was only observed in Kenya (2.3%); NTS isolates were susceptible to ciprofloxacin at all sites. CONCLUSIONS: Understanding variability in serovar distribution will be important for the future deployment of vaccines against salmonellosis in Africa.","journal":"Clinical Infectious Diseases","year":2023,"id":367951,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8984,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":917572,"name":"Helen Powell","orcid":"0000-0002-6145-6226","position":1,"is_corresponding":false},{"id":479281,"name":"Richard Omore","orcid":"0000-0003-3702-3030","position":2,"is_corresponding":false},{"id":479278,"name":"M Jahangir Hossain","orcid":"0000-0002-8415-3180","position":3,"is_corresponding":false},{"id":299788,"name":"Samba O. Sow","orcid":"0000-0002-6335-5066","position":4,"is_corresponding":false},{"id":1068459,"name":"John B. Ochieng","orcid":"0000-0002-5301-4559","position":5,"is_corresponding":false},{"id":821364,"name":"Henry Badji","orcid":"0000-0003-3681-5976","position":6,"is_corresponding":false},{"id":616173,"name":"Jennifer R. Verani","orcid":"0000-0001-5267-1883","position":7,"is_corresponding":false},{"id":227044,"name":"Marc‐Alain Widdowson","orcid":"0000-0002-0682-6933","position":8,"is_corresponding":false},{"id":1125929,"name":"Sunil Kumar Sen","orcid":null,"position":9,"is_corresponding":false},{"id":742243,"name":"Shamima Nasrin","orcid":"0000-0002-7643-0096","position":10,"is_corresponding":false},{"id":1125930,"name":"Jasnehta Permala-Booth","orcid":null,"position":11,"is_corresponding":false},{"id":742245,"name":"Jennifer Jones","orcid":"0000-0001-6898-2862","position":12,"is_corresponding":false},{"id":479282,"name":"Anna Roose","orcid":"0000-0001-7020-0380","position":13,"is_corresponding":false},{"id":821941,"name":"Dilruba Nasrin","orcid":null,"position":14,"is_corresponding":false},{"id":1076492,"name":"Ciara E Sugerman","orcid":null,"position":15,"is_corresponding":false},{"id":1108841,"name":"Jane Juma","orcid":null,"position":16,"is_corresponding":false},{"id":1064685,"name":"Alex O Awuor","orcid":"0009-0003-9138-7748","position":17,"is_corresponding":false},{"id":1064684,"name":"Joquina Chiquita M Jones","orcid":"0009-0001-4213-1493","position":18,"is_corresponding":false},{"id":908757,"name":"Doh Sanogo","orcid":null,"position":19,"is_corresponding":false},{"id":497118,"name":"Catherine Okoi","orcid":"0000-0003-2412-852X","position":20,"is_corresponding":false},{"id":1068458,"name":"Syed M. A. Zaman","orcid":"0000-0001-7556-7114","position":21,"is_corresponding":false},{"id":242150,"name":"Martín Antonio","orcid":"0000-0002-4810-1308","position":22,"is_corresponding":false},{"id":653371,"name":"Elizabeth Hunsperger","orcid":"0000-0002-4450-621X","position":23,"is_corresponding":false},{"id":1125557,"name":"Clayton Onyango","orcid":"0000-0003-3418-5042","position":24,"is_corresponding":false},{"id":289244,"name":"James A Platts-Mills","orcid":"0000-0002-4956-0418","position":25,"is_corresponding":false},{"id":289247,"name":"Jie Liu","orcid":"0000-0003-2658-5249","position":26,"is_corresponding":false},{"id":289258,"name":"Eric R. Houpt","orcid":"0000-0003-1085-1354","position":27,"is_corresponding":false},{"id":38212,"name":"Kathleen M. Neuzil","orcid":"0000-0001-9480-2714","position":28,"is_corresponding":false},{"id":242121,"name":"Karen L. Kotloff","orcid":"0000-0003-1808-6431","position":29,"is_corresponding":false},{"id":260735,"name":"Sharon M. Tennant","orcid":"0000-0002-0651-5748","position":30,"is_corresponding":false},{"id":1069031,"name":"Irene N Kasumba","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:15:16.306414Z","pmid":"37074429","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}