{"doi":"10.1093/cid/ciac824","title":"Impact of Point-of-Care Testing on the Management of Sexually Transmitted Infections in South Africa: Evidence from the HVTN702 Human Immunodeficiency Virus Vaccine Trial","abstract":"BACKGROUND: Alternative approaches to syndromic management are needed to reduce rates of sexually transmitted infections (STIs) in resource-limited settings. We investigated the impact of point-of-care (POC) versus central laboratory-based testing on STI treatment initiation and STI adverse event (STI-AE) reporting. METHODS: We used Kaplan-Meier and Cox regression models to compare times to treatment initiation and STI-AE reporting among HVTN702 trial participants in South Africa. Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) were diagnosed POC at eThekwini clinic and in a central laboratory at Verulam/Isipingo clinics. All clinics used POC assays for Trichomonas vaginalis (TV) testing. RESULTS: Among 959 women (median age, 23 [interquartile range, 21-26] years), median days (95% confidence interval [95%CI]) to NG/CT treatment initiation and NG/CT-AE reporting were 0.20 (.16-.25) and 0.24 (.19-.27) at eThekwini versus 14.22 (14.12-15.09) and 15.12 (13.22-21.24) at Verulam/Isipingo (all P < .001). Median days (95%CI) to TV treatment initiation and TV-AE reporting were 0.17 (.12-.27) and 0.25 (.20-.99) at eThekwini versus 0.18 (.15-.2) and 0.24 (.15-.99) at Verulam/Isipingo (all P > .05). Cox regression analysis revealed that NG/CT treatment initiation (adjusted hazard ratio [aHR], 39.62 [95%CI, 15.13-103.74]) and NG/CT-AE reporting (aHR, 3.38 [95%CI, 2.23-5.13]) occurred faster at eThekwini versus Verulam/Isipingo, while times to TV treatment initiation (aHR, 0.93 [95%CI, .59-1.48]) and TV-AE reporting (aHR, 1.38 [95%CI, .86-2.21]) were similar. CONCLUSIONS: POC testing led to prompt STI management with potential therapeutic and prevention benefits, highlighting its utility as a diagnostic tool in resource-limited settings.","journal":"Clinical Infectious Diseases","year":2022,"id":263596,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8905,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":921185,"name":"Tsion Andine","orcid":null,"position":1,"is_corresponding":false},{"id":437685,"name":"Nivashnee Naicker","orcid":"0000-0002-8819-3825","position":2,"is_corresponding":false},{"id":437684,"name":"Jienchi Dorward","orcid":"0000-0001-6072-1430","position":3,"is_corresponding":false},{"id":635573,"name":"Nishanta Singh","orcid":null,"position":4,"is_corresponding":false},{"id":651079,"name":"Elizabeth Spooner","orcid":"0000-0002-1498-8131","position":5,"is_corresponding":false},{"id":589417,"name":"Jessica Andriesen","orcid":"0000-0002-2016-8500","position":6,"is_corresponding":false},{"id":386730,"name":"Farzana Osman","orcid":null,"position":7,"is_corresponding":false},{"id":385884,"name":"Sinaye Ngcapu","orcid":"0000-0002-9625-8131","position":8,"is_corresponding":false},{"id":408746,"name":"Alain Vandormael","orcid":"0000-0002-5742-0511","position":9,"is_corresponding":false},{"id":596206,"name":"Adrian Mindel","orcid":"0000-0002-8780-9982","position":10,"is_corresponding":false},{"id":385888,"name":"Salim S. Abdool Karim","orcid":"0000-0002-4986-2133","position":11,"is_corresponding":false},{"id":273592,"name":"Linda‐Gail Bekker","orcid":"0000-0002-0755-4386","position":12,"is_corresponding":false},{"id":314444,"name":"Glenda Gray","orcid":"0000-0003-4649-1477","position":13,"is_corresponding":false},{"id":96348,"name":"Lawrence Corey","orcid":"0000-0002-2179-2436","position":14,"is_corresponding":false},{"id":446166,"name":"Andrew Tomita","orcid":"0000-0003-3545-2317","position":15,"is_corresponding":false},{"id":331062,"name":"Nigel Garrett","orcid":"0000-0002-4530-234X","position":16,"is_corresponding":false},{"id":920608,"name":"Kwabena Asare","orcid":"0000-0002-5074-2315","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:26:33.413850Z","pmid":"36250382","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}