{"doi":"10.1093/cid/ciac821","title":"Improved Survival After Liver Transplantation for Patients With Human Immunodeficiency Virus (HIV) and HIV/Hepatitis C Virus Coinfection in the Integrase Strand Transfer Inhibitor and Direct-Acting Antiviral Eras","abstract":"BACKGROUND: People with human immunodeficiency virus (HIV) with and without hepatitis C virus (HCV) coinfection had poor outcomes after liver transplant (LT). Integrase strand transfer inhibitors (INSTIs) and direct-acting antivirals (DAAs) have changed the treatment landscape for HIV and HCV, respectively, but their impact on LT outcomes remains unclear. METHODS: This retrospective analysis of adults with HIV monoinfection (n = 246) and HIV/HCV coinfection (n = 286) who received LT compared mortality in patients with HIV who received LT before versus after approval of INSTIs and in patients with HIV/HCV coinfection who received LT before versus after approval of DAAs. In secondary analysis, we compared the outcomes in the different eras with those of propensity score-matched control cohorts of LT recipients without HIV or HCV infection. RESULTS: LT recipients with HIV monoinfection did not experience a significant improvement in survival between the pre-INSTI and INSTI recipients with HIV (adjusted hazard ratio [aHR], 0.70 [95% confidence interval {CI}, .36-1.34]). However, recipients with HIV/HCV coinfection in the DAA era had a 47% reduction (aHR, 0.53 [95% CI, .31-9.2] in 1-year mortality compared with coinfected recipients in the pre-DAA era. Compared to recipients without HIV or HCV, HIV-monoinfected recipients had higher mortality during the pre-INSTI era, but survival was comparable between groups during the INSTI era. HIV/HCV-coinfected recipients also experienced comparable survival during the DAA era compared to recipients without HCV or HIV. CONCLUSIONS: Post-LT survival for people with HIV monoinfection and HIV/HCV coinfection has improved with the introduction of INSTI and DAA therapy, suggesting that LT has become safer in these populations.","journal":"Clinical Infectious Diseases","year":2022,"id":275825,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":945867,"name":"Anjiya Shaikh","orcid":null,"position":1,"is_corresponding":false},{"id":945868,"name":"Karthik Goli","orcid":null,"position":2,"is_corresponding":false},{"id":233438,"name":"Nicole E. Rich","orcid":"0000-0003-2740-8818","position":3,"is_corresponding":false},{"id":278348,"name":"Jihane N. Benhammou","orcid":"0000-0003-2442-5145","position":4,"is_corresponding":false},{"id":243164,"name":"Aijaz Ahmed","orcid":"0000-0002-3609-8586","position":5,"is_corresponding":false},{"id":239483,"name":"Donghee Kim","orcid":"0000-0003-1919-6800","position":6,"is_corresponding":false},{"id":945400,"name":"Abbas Rana","orcid":"0000-0003-2979-0598","position":7,"is_corresponding":false},{"id":826312,"name":"John A. Goss","orcid":"0000-0001-7999-2900","position":8,"is_corresponding":false},{"id":3885,"name":"Susanna Naggie","orcid":"0000-0001-7721-6975","position":9,"is_corresponding":false},{"id":243401,"name":"Tzu-Hao Lee","orcid":null,"position":10,"is_corresponding":false},{"id":233864,"name":"Fasiha Kanwal","orcid":"0000-0001-6715-3966","position":11,"is_corresponding":false},{"id":945401,"name":"George Cholankeril","orcid":"0000-0002-5871-6031","position":12,"is_corresponding":false},{"id":945399,"name":"Jake Jacob","orcid":"0000-0001-8180-3080","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T00:28:21.971703Z","pmid":"36221143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}