{"doi":"10.1093/cid/ciac337","title":"Human Immunodeficiency Virus Is Associated With Elevated FibroScan–Aspartate Aminotransferase (FAST) Score","abstract":"BACKGROUND: Whether human immunodeficiency virus (HIV) infection is associated with the development of nonalcoholic steatohepatitis (NASH) remains unclear. The FibroScan-aspartate aminotransferase (FAST) score was developed to identify patients who have histologic NASH with high nonalcoholic fatty liver disease activity score (NAS ≥4) and significant liver fibrosis (≥F2), which has been associated with higher risk of end-stage liver disease. We examined whether HIV infection is associated with elevated FAST score in a large United States (US) cohort. METHODS: Vibration-controlled transient elastography was performed in 1309 women without history of chronic viral hepatitis enrolled from 10 US sites: 928 women with HIV (WWH) and 381 women without HIV (WWOH). We used multivariable logistic regression to evaluate associations of HIV, demographic, lifestyle, and metabolic factors with an elevated (>0.35) FAST score. RESULTS: Median age of WWH and WWOH was 51 years and 48 years, respectively. Most (90%) WWH were on antiretroviral therapy and 72% had undetectable HIV RNA. Prevalence of elevated FAST score was higher among WWH compared to WWOH (6.3% vs 1.8%, respectively; P = .001). On multivariable analysis, HIV infection was associated with 3.7-fold higher odds of elevated FAST score (P = .002), and greater waist circumference (per 10 cm) was associated with 1.7-fold higher odds (P < .001). In analysis limited to WWH, undetectable HIV RNA and current protease inhibitor use were independently associated with lower odds of elevated FAST score. CONCLUSIONS: Our findings suggest that HIV is an independent risk factor for NASH with significant activity and fibrosis. Studies validating FAST score in persons with HIV are warranted.","journal":"Clinical Infectious Diseases","year":2022,"id":258617,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9661,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":910167,"name":"Yifei Ma","orcid":"0000-0003-3326-0098","position":1,"is_corresponding":false},{"id":425717,"name":"Mark H. Kuniholm","orcid":"0000-0002-0173-9806","position":2,"is_corresponding":false},{"id":301953,"name":"Adaora A. Adimora","orcid":"0000-0001-5035-1552","position":3,"is_corresponding":false},{"id":301952,"name":"Margaret A. Fischl","orcid":"0000-0001-9241-5390","position":4,"is_corresponding":false},{"id":301950,"name":"Audrey L. French","orcid":"0000-0002-9776-8934","position":5,"is_corresponding":false},{"id":301949,"name":"Elizabeth T. Golub","orcid":"0000-0001-5860-4913","position":6,"is_corresponding":false},{"id":404729,"name":"Deborah Konkle‐Parker","orcid":"0000-0002-3319-8442","position":7,"is_corresponding":false},{"id":382868,"name":"Howard Minkoff","orcid":"0000-0002-7800-7195","position":8,"is_corresponding":false},{"id":303364,"name":"Ighovwerha Ofotokun","orcid":null,"position":9,"is_corresponding":false},{"id":404159,"name":"Michael Plankey","orcid":"0000-0003-4554-7483","position":10,"is_corresponding":false},{"id":329435,"name":"Anjali Sharma","orcid":"0000-0003-3717-025X","position":11,"is_corresponding":false},{"id":150354,"name":"Phyllis C. Tien","orcid":null,"position":12,"is_corresponding":false},{"id":315360,"name":"Jennifer C. Price","orcid":"0000-0002-3825-5696","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:43.037820Z","pmid":"35511608","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}