{"doi":"10.1093/cid/ciac326","title":"The Impact of Vitamin A Deficiency on Tuberculosis Progression","abstract":"BACKGROUND: Although previous studies have shown that vitamin A deficiency is associated with incident tuberculosis (TB) disease, the direction of the association has not been established. We investigated the impact of vitamin A deficiency on TB disease progression. METHODS: We conducted a longitudinal cohort study nested within a randomized clinical trial among HIV-infected patients in Haiti. We compared serial vitamin A levels in individuals who developed TB disease to controls matched on age, gender, follow-up time, and time to antiretroviral therapy initiation. We also evaluated histopathology, bacterial load, and immune outcomes in TB infection in a guinea pig model of dietary vitamin A deficiency. RESULTS: Among 773 participants, 96 developed incident TB during follow-up, 62.5% (60) of whom had stored serum samples obtained 90-365 days before TB diagnosis. In age- and sex- adjusted and multivariate analyses, respectively, incident TB cases were 3.99 times (95% confidence interval [CI], 2.41 to 6.60) and 3.59 times (95% CI, 2.05 to 6.29) more likely to have been vitamin A deficient than matched controls. Vitamin A-deficient guinea pigs manifested more extensive pulmonary pathology, atypical granuloma morphology, and increased bacterial growth after experimental TB infection. Reintroduction of dietary vitamin A to deficient guinea pigs after established TB disease successfully abrogated severe disease manifestations and altered cellular immune profiles. CONCLUSIONS: Human and animal studies support the role of baseline vitamin A deficiency as a determinant of future TB disease progression.","journal":"Clinical Infectious Diseases","year":2022,"id":256339,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9392,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905201,"name":"Omowunmi Aibana","orcid":"0000-0003-0665-5393","position":1,"is_corresponding":false},{"id":392985,"name":"Chuan-Chin Huang","orcid":"0000-0002-8775-3755","position":2,"is_corresponding":false},{"id":394806,"name":"James E. DiLisio","orcid":"0000-0001-9216-0375","position":3,"is_corresponding":false},{"id":905599,"name":"Macallister C Harris","orcid":null,"position":4,"is_corresponding":false},{"id":300168,"name":"David F. Ackart","orcid":null,"position":5,"is_corresponding":false},{"id":905600,"name":"Kody Armann","orcid":null,"position":6,"is_corresponding":false},{"id":905601,"name":"Alexander Grover","orcid":null,"position":7,"is_corresponding":false},{"id":537084,"name":"Patrice Sévère","orcid":null,"position":8,"is_corresponding":false},{"id":905602,"name":"Marc Antoine Jean Juste","orcid":null,"position":9,"is_corresponding":false},{"id":446862,"name":"Kathryn Dupnik","orcid":"0000-0001-7100-2917","position":10,"is_corresponding":false},{"id":298396,"name":"Randall J. Basaraba","orcid":"0000-0002-3593-5012","position":11,"is_corresponding":false},{"id":231936,"name":"Megan Murray","orcid":"0000-0003-0443-1986","position":12,"is_corresponding":false},{"id":394809,"name":"Brendan K. Podell","orcid":"0000-0003-2548-8826","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:21.336200Z","pmid":"35486953","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}